Time-dependent effects of nicotine on serum glucose, albumin, urea, uric acid, and liver histology in rat | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| Volume 13, Issue 2 - Serial Number 50, March 2025, Pages 67-75 PDF (1012.55 K) | ||
| Document Type: Article | ||
| DOI: 10.30473/eab.2025.72323.1965 | ||
| Authors | ||
| Parinaz Hajiyousefipour; Mehdi Basaki* ; Davoud Kianifard; Yousef Panahi; Mehri Anisi | ||
| Department of Basic Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran | ||
| Abstract | ||
| Nicotine is a natural alkaloid and the primary cause of tobacco addiction. Nicotine stimulates the brain, raises blood pressure and heart rate, increases metabolic rate, suppresses appetite, and regulates body weight through binding to nicotinic acetylcholine receptors (nAChRs). Nicotine causes weight loss, enzyme leakage, lipid peroxidation, and oxidative stress in the liver. To investigate the time-dependent effects of nicotine on liver function rats were injected intraperitoneally daily with of nicotine (2 mg/kg). Forty blood samples were taken at four stages, as four independent groups, before nicotine administration and 30 minutes, one week, and four weeks after the first nicotine administration. Serum glucose, albumin, urea, and uric acid were measured by standard methods. After four weeks of nicotine administration, liver samples were fixed in a 10% formaldehyde solution, and diameters of the central vein, hepatocyte, and sinusoid and thickness of the liver capsule were measured. Short and long-term nicotine administration decreased serum glucose and albumin. Serum urea and uric acid decreased following immediate, short-term, and long-term nicotine administration. Also, the diameter of hepatocytes and sinusoids increased after four weeks of nicotine administration. Nicotine reduces hepatic synthesis of glucose, albumin, urea, and uric acid time-dependently through various regulatory mechanisms. Investigating nicotine's effects on the genes and enzymes involved in liver metabolism will help to clarify the molecular mechanisms of nicotine's effects. | ||
| Keywords | ||
| Nicotine; glucose; albumin; urea; uric acid; liver | ||
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