پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 49 |
| تعداد شمارهها | 1,317 |
| تعداد مقالات | 11,387 |
| تعداد مشاهده مقاله | 24,353,954 |
| تعداد دریافت فایل اصل مقاله | 16,279,286 |
بررسی عددی شاخص اختلاط میکرومیکسر الکترواسموتیک بهبودیافته با استفاده از الکترودهای متمرکز در ساختار هندسی نامتقارن جانبی | ||
| فصلنامه علمی اپتوالکترونیک | ||
| دوره 8، شماره 2 - شماره پیاپی 23، دی 1404، صفحه 39-54 اصل مقاله (1.97 M) | ||
| نوع مقاله: پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/jphys.2025.73953.1238 | ||
| نویسنده | ||
| پریسا محمودی* | ||
| گروه مهندسی برق، دانشگاه پیام نور، تهران، ایران | ||
| چکیده | ||
| در بسیاری از فرآیندهای بیوشیمیایی، اختلاط موثر نمونه ها در زمان کم مورد نیاز می باشد. لیکن، اختلاط سریع و همگن سیال های مختلف در کانال های میکروفلوئیدیک، به دلیل عدد رینولدز پایین مرتبط با جریال سیال دشوار است. در این مقاله یک میکرومیکسر فعال با هندسۀ نامتقارن جانبی ارائه شده است، که به واسطۀ شکل آن امکان اعمال جریان الکترواسموتیک نزدیک به ورودی و به ویژه در خروجی محفظۀ اختلاط میکسر فراهم می شود. در این پیکربندی، سیال های ورودی به ازای دامنۀ ولتاژهای بسیار کوچک، سریع تر و متمرکزتر تحت تاثیر اختلاط موثر قرار می گیرند. به این ترتیب کیفیت بالاتری از مخلوط آنها در طول محفظۀ اختلاط، تحت تاثیر گرداب های ناشی از تحریک الکترواسموتیک و همچنین لبه های تیز داخل محفظه، جاری می شود. کیفیت اختلاط حاصل بار دیگر به واسطۀ میدان الکتریکی دهانۀ خروجی محفظه، دستخوش تغییر می گردد. این عملکرد سبب کاهش زمان اختلاط موثر، کاهش دامنۀ ولتاژ اعمالی، بهبود شاخص اختلاط و ثبات و پایداری عملکرد میکسر در طول زمان می شود. طبق نتایج شبیه سازی المان محدود، به ازای ولتاژ تحریک 1/0 ولت، زمان اختلاط کمتر از 2 ثانیه و شاخص اختلاط 98/0 می باشد. درنتیجه، این طراحی برای کاربردهای آزمایشگاه بر تراشۀ میکروفلوئیدیک، که ماهیت نمونه ها در میکسرها باید بدون تغییر بماند، بسیار ایمن و کارآمد است. | ||
| کلیدواژهها | ||
| میکرومیکسر؛ الکترواسموتیک؛ الکترود؛ غلظت؛ شاخص اختلاط | ||
| عنوان مقاله [English] | ||
| Numerical Investigation of the Mixing Index for an Enhanced Electroosmotic Micro-Mixer Using Focused Electrodes in a Non-symmetric Lateral Geometry | ||
| نویسندگان [English] | ||
| Parisa Mahmoudi | ||
| Department of Electrical Engineering, Payame Noor University (PNU), Tehran, Iran | ||
| چکیده [English] | ||
| Effective mixing of samples is a critical requirement in many biochemical processes. However, achieving fast and homogeneous mixing in microfluidic channels presents significant challenges due to the low Reynolds number characteristic of microscale fluid flows. This study introduces an active micromixer with a non-symmetric lateral geometry that facilitates the application of electroosmotic flow, particularly near the inlet and, most notably, at the outlet of the mixing chamber. In this proposed configuration, input fluids are more rapidly and precisely subjected to efficient mixing, under very low applied voltages. As a result, a higher quality of fluid mixture is achieved throughout the mixing chamber, driven by vortices generated through electroosmotic stimulation as well as the sharp edges within the chamber. Additionally, the mixing quality is further modified by the electric field at the outlet of the mixing chamber. This performance reduces the effective mixing time, minimizes the required voltage amplitude, improves the Mixing Index, and ensures consistent and stable operation over time. According to the finite element simulation results, at an applied voltage of 0.1 volts, the mixing time is less than 2 seconds, and the Mixing Index is 0.98. Consequently, this design is highly safe and efficient for lab-on-a-chip microfluidic applications, where the integrity of the samples within the mixers must remain unchanged. | ||
| کلیدواژهها [English] | ||
| Micromixer, Electroosmotic, Electrode, Concentration, Mixing Index | ||
| مراجع | ||
|
[1] Nguyen, N.-T., Hejazian, M., Ooi, C. H., Kashaninejad, N. (2017). Recent Advances and Future Perspectives on Microfluidic Liquid Handling. Micromachines, 8(6), 186. DOI: 10.3390/mi8060186.
[2] Niculescu, A. G., Chircov, C., Bîrcă, A. C., Grumezescu, A. M. (2021). Fabrication and Applications of Microfluidic Devices: A Review. Int J Mol Sci, 22(4), 2011. DOI: 10.3390/ijms22042011.
[3] Gharib, G., Bütün, İ., Muganlı, Z., Kozalak, G., Namlı, İ., Sarraf, S. S., et al. (2022). Biomedical Applications of Microfluidic Devices: A Review. Biosensors, 12(11), 1023. DOI: 10.3390/bios12111023.
[4] Convery, N., Gadegaard, N. (2019). 30 Years of Microfluidics. Micro and Nano Engineering, 2, 76-91. DOI: 10.1016/j.mne.2019.01.003.
[5] Bayareh, M., Nazemi, A. M., Usefian, A. (2020). Active and Passive Micromixers: A Comprehensive Review. Chem Eng Process- Process Intensif. 147, 107771. DOI: 10.1016/j.cep.2019.107771.
[6] Lee, C. Y., Chang, C. L., Wang, Y. N., Fu, L. M. (2011). Microfluidic Mixing: A Review. Int J Mol Sci. 12(5), 3263-87. DOI: 10.3390/ijms12053263.
[7] Gande, V. V., Podupu, P. K. R., Berry, B., Nere, N. K., Pushpavanam, S., Singh, M. R. (2024). Engineering Advancements in Microfluidic Systems for Enhanced Mixing at Low Reynolds Numbers. Biomicrofluidics, 18(1), 011502. DOI: 10.1063/5.0178939.
[8] Lee, C.-Y. Fu, L.-M. (2018). Recent Advances and Applications of Micromixers. J. Sensors and Actuators B: Chemical, 259, 677 —702. DOI: 10.1016/j.snb.2017.12.034.
[9] Raza, W., Hossain, S., Kim, K.-Y. (2020). A Review of Passive Micromixers with a Comparative Analysis. Micromachines, 11(5), 455. DOI: 10.3390/mi11050455.
[10] Ober, T.J., Foresti, D., Lewis, J.A. (2015). Active Mixing of Complex Fluids at the Microscale. Proc Natl Acad Sci U S A, 112(40), 12293-8. DOI: 10.1073/pnas.1509224112.
[11] Bazaz, S. R., Mehrizi, A. A., Ghorbani, S., Vasilescu, S., Asadnia, M., Warkiani, M. E. (2018). A Hybrid Micromixer with Planar Mixing Units. RSC Adv, 8(58), 33103-33120. DOI: 10.1039/c8ra05763j.
[12] Youliang, C., Yan, J., Wenyang, W. (2018). Numerical Simulation for Electro-osmotic Mixing under Three Types of Periodic Potentials in a T-shaped Micro-Mixer. Chemical Engineering and Processing- Process Intensification, 127, 93-102. DOI: 10.1016/j.cep.2018.03.017.
[13] Chen, Z., Wang, Y., Zhou, S. (2022). Numerical Analysis of Mixing Performance in an Electroosmotic Micromixer with Cosine Channel Walls. Micromachines, 13(11), 1933. DOI: 10.3390/mi13111933.
[14] García-Sánchez, P., Ramos, A. (2012). AC Electroosmosis: Basics and Lab-on-a-Chip Applications. Bhushan, B. (eds) Encyclopedia of Nanotechnology. Springer, Dordrecht. DOI:10.1007/978-90-481-9751-4_125.
[15] Feeoj, R. K., Eshkaftaki, S. M. A., Asfeh, I. K., Jahangiri, M. (2022). Finite-element Simulation of Electroosmotic Mixing: A Study of the Simultaneous Effects of Working Parameters for Optimization. Int. J Chem Eng, 9957189. DOI: 10.1155/2022/9957189 ·
[16] Gayen, B., Manna, N. K., Biswas, N. (2023). Enhanced Mixing Quality of Ring-type Electroosmotic Micromixer Using Baffles. Chemical Engineering and Processing: Process Intensification, 189, 109381. DOI: 10.1016/j.cep.2023.109381.
[17] Saravanakumar, S. M., Jamshidi Seresht, M., Izquierdo, R., Cicek, P.-V. (2024). A Novel DC Electroosmotic Micromixer Based on Helical Vortices. Actuators, 13(4), 139. DOI: 10.3390/act13040139.
[18] Nouri, D., Hesari, A.Z., Passandideh-Fard, M. (2017). Rapid Mixing in Micromixers Using Magnetic Field. Sensors Actuators A Phys, 255. 79–86. DOI: 10.1016/j.sna.2017.01.005.
[19] Hejazian, M., Nguyen, N.T. (2017). A Rapid Magnetofluidic Micromixer Using Diluted Ferrofluid. Micromachines, 8 (2), 37. DOI: 10.3390/mi8020037.
[20] Petkovic, K., Metcalfe, G., Chen, H. (2017). Rapid Detection of Hendra Virus Antibodies: An Integrated Device with Nanoparticle Assay and Chaotic Micromixing. Lab Chip, 17 (1), 169–177. DOI: 10.1039/C6LC01263A.
[21] Lim, E., Lee, L., Yeo, L. Y., Hung, Y. M., Tan, M. K. (2019). Acoustically-Driven Micromixing: Effect of Transducer Geometry. IEEE Trans Ultrason Ferroelectr Freq Control, 4. DOI:10.1109/TUFFC.2019.2920683.
[22] Lu, Y., Tan, W., Mu, S., Zhu, G. (2022). A Multi-Vortex Micromixer Based on the Synergy of Acoustics and Inertia for Nanoparticle Synthesis. Anal Chim Acta, 1239, 340742. DOI: 10.1016/j.aca.2022.340742.
[23] Wu, J. W., Xia, H. M., Zhang, Y. Y., Zhao, S. F., Zhu, P., Wang, Z. P. (2018). An Efficient Micromixer Combining Oscillatory Flow and Divergent Circular Chambers. Microsyst Technol, 25 (7), 2741–2750. DOI: 10.1007/s00542-018-4193-7.
[24] Li, Z., Kim, S.-J. (2017). Pulsatile Micromixing Using Water-Head-Driven Microfluidic Oscillators. Chem. Eng. J, 313, 1364–1369. DOI: 10.1016/j.cej.2016.11.056.
[25] Zhang, M., Zhang, W., Wu, Z., Shen, Y., Chen, Y., Lan, C., et al. (2019). Comparison of Micro-Mixing in Time Pulsed Newtonian Fluid and Viscoelastic Fluid. Micromachines, 10 (4), 262. DOI: 10.3390/mi10040262.
[26] Hossan, M. R., Dutta, D., Islam, N., Dutta, P. (2018). Review: Electric Field Driven Pumping in Microfluidic Device. Electrophoresis, 39(5-6), 702-731. DOI: 10.1002/elps.201700375.
[27] Farahinia, A., Jamaati, J., Niazmand, H., Zhang, W.J. (2019). Investigation of An Electro-osmotic Micromixer with Heterogeneous Zeta-potential Distribution at the Wall. Engineering Research Express, 1. DOI: 10.1088/2631-8695/ab3a15.
[28] Mei, L., Cui, D., Shen, J., Dutta, D., Brown, W., Zhang, L., et al. (2021). Electroosmotic Mixing of Non-Newtonian Fluid in a Microchannel with Obstacles and Zeta Potential Heterogeneity. Micromachines (Basel), 12(4), 431. DOI: 10.3390/mi12040431.
[29] Wang, X., Xu, H., Qi, H. (2023). Induced-charge Electroosmosis Flow of Viscoelastic Fluids under Different Voltage Arrangements. Phys Fluids, 35, 113115. DOI: 10.1063/5.0177718.
[30] Ammar, H., Zoghbi, B.E., Faraj, J., Khaled, M. (2025). Enhanced Micromixer Designs for Chemical Applications – Numerical Simulations and Analysis. Chemical Engineering and Processing - Process Intensification, 208, 110098. DOI:10.1016/j.cep.2024.110098.
[31] Bagherabadi, K. M., Sani, M., Saidi, M. S. (2019). Enhancing Active Electro-Kinetic Micro-Mixer Efficiency by Introducing Vertical Electrodes and Modifying Chamber Aspect Ratio. Chem Eng Process- Process Intensif. 142, 107560. DOI: 10.1016/j.cep.2019.107560.
[32] Jalili, H., Raad, M., Fallah, D. A. (2020). Numerical Study on the Mixing Quality of an Electroosmotic Micromixer under Periodic Potential. Proceedings of the Institution of Mechanical Engineers, Part C: Journal of Mechanical Engineering Science, 234(11), 2113-2125. DOI:10.1177/0954406220904089.
[33] Saravanakumar, S. M., Cicek, P.-V. (2023). Microfluidic Mixing: A Physics-Oriented Review. Micromachines, 14(10), 1827. DOI: 10.3390/mi14101827.
[34] Habibi, A., Shojaei, S., Tehrani, P. (2019). A Comparative Numerical Design of the Static and Electrostatic Micromixers. SN Appl Sci, 1, 506. DOI: 10.1007/s42452-019-0491-7.
[35] Mondal, B., Mehta, S. K., Pati, S., Patowari, P. K. (2021). Numerical Analysis of Electroosmotic Mixing in a Heterogeneous Charged Micromixer with Obstacles. Chem Eng Process- Process Intensif. 168, 108585 (2021). DOI: 10.1016/j.cep.2021.108585.
[36] Rashidi, S., Bafekr, H., Valipour, M. S., Esfahani, J. A. (2018). A Review on the Application, Simulation, and Experiment of the Electrokinetic Mixers. Chem. Eng. Process. Process Intensif, 126, 108–122. DOI: 10.1016/j.cep.2018.02.021.
[37] Mehta, S. K., Mondal, B., Pati, S., Patowari, P. K. (2022). Enhanced Electroosmotic Mixing of Non-Newtonian Fluids in a Heterogeneous Surface Charged Micromixer with Obstacles. Colloids Surf. A 648, 129215. DOI: 10.1016/j.colsurfa.2022.129215.
[38] Kumar, A., Manna, N. K., Sarkar, S. (2023). Effect of Electrode Length and AC Frequency on Mixing in a Diamond-Shaped Split-and-Recombine Electroosmotic Micromixer. Recent Advancements in Mechanical Engineering, Springer Nature, 83–92. DOI:10.1007/978-981-19-3266-3_7.
[39] Xu, Y.-J., Nazeer, M., Hussain, F., Khan, M. I., Hameed, M. K., Shah, N. A., et al. (2021). Electro-osmotic Flow of Biological Fluid in Divergent Channel: Drug Therapy in Compressed Capillaries. Sci Rep, 11, 23652. DOI: 10.1038/s41598-021-03087-0.
[40] Mehta, S. K., Pati, S., Mondal, P. K. (2021). Numerical Study of the Vortex‐Induced Electroosmotic Mixing of Non‐Newtonian Biofluids in a Nonuniformly Charged Wavy Microchannel: Effect of finite Ion Size. Electrophoresis, 42(23), 2498–2510. DOI: DOI: 10.1002/elps.202000225. | ||
|
آمار تعداد مشاهده مقاله: 573 تعداد دریافت فایل اصل مقاله: 387 |
||