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اثرات عصاره هیدروالکلی مریمگلی بر سرطان پستان در موش صحرایی | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| دوره 13، شماره 4 - شماره پیاپی 52، آبان 1404، صفحه 1-11 اصل مقاله (762.94 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2025.75303.2002 | ||
| نویسندگان | ||
| حبیبه زارع1؛ نعیمه دهقانی* 2؛ حامد دانش پژوه2 | ||
| 1گروه زیستشناسی، دانشکده علوم پایه، دانشگاه شیراز، شیراز، ایران | ||
| 2گروه زیستشناسی، دانشگاه پیام نور، تهران، ایران | ||
| چکیده | ||
| منابع طبیعی مانند گیاهان، یک گزینه درمانی مطمئن در درمان سرطانها و کاهش عوارض جانبی روشهای درمانی فعلی هستند. مریمگلی یک گیاه معطر و دارویی است که بهدلیل خواص آنتیاکسیدانی خود شناخته شده است. این گیاه بهعنوان یک عامل ضد اسپاسم، قابض، آرامبخش، ضد قند خون و ضد التهاب در طب ایرانی مورداستفاده قرار گرفته است. در پژوهش حاضر مطالعه اثرات ضد سرطانی ترکیبات موجود در عصارههای مریمگلی، مانند سینئول و کافور انجام گرفت. بدین منظور ابتدا در موشها، سرطان توسط دیمتیلبنز آنتراسن (دیمتیلبنزانتراسن) حل شده در روغن کنجد بهمدت چهار هفته القا شد. سپس ردههای سلولی توموری مختلف در معرض عصاره مریمگلی قرار گرفتند. بدین منظور گروه مورد آزمایش بهمدت چهار هفته با عصاره هیدروالکلی برگ مریمگلی درمان شدند. درحالیکه گروه کنترل آب مقطر دریافت کردند. سپس مقاطع بافتی از نمونهها گرفته شده و گروهها با یکدیگر از نظر آماری مقایسه گردیدند. یافتهها نشاندهنده اثرات درمانی مریمگلی بر سرطان القاشده میباشد. مریمگلی میتواند بهطور بالقوه از سرطان پستان جلوگیری کند. | ||
| کلیدواژهها | ||
| مریمگلی؛ سرطان؛ پستان؛ موش | ||
| عنوان مقاله [English] | ||
| Effects of alcoholic extract of Salvia officinalis on rat to prevent Breast cancer | ||
| نویسندگان [English] | ||
| Habibe Zare1؛ Naeimeh Dehghani2؛ Hamed Daneshpazhouh2 | ||
| 1Department of Biology, University of Shiraz, Shiraz, Iran | ||
| 2Department of Biology, Payame Noor University, Tehran, Iran | ||
| چکیده [English] | ||
| Natural resources such as plants are a safe therapeutic option in treating cancers and reducing the side effects of current treatments. Sage is an aromatic and medicinal plant known for its antioxidant properties. It has been used as an antispasmodic, astringent, sedative, anti-hyperglycemic, and anti-inflammatory agent in Iranian medicine. In the present study, the anticancer effects of compounds found in sage extracts, such as cineole and camphor, were studied. For this purpose, cancer was first induced in mice by (dimethylbenzanthracene) dissolved in sunflower oil for 4 weeks. Then, different tumor cell lines were exposed to the extracts. For this purpose, the experimental group was treated with a hydroalcoholic extract of sage leaves for 4 weeks. While the control group received distilled water. Then, tissue sections were taken from the samples and the groups were statistically compared with each other. The findings indicate the therapeutic effects of sage. Sage can potentially prevent breast cancer. | ||
| کلیدواژهها [English] | ||
| Salvia officinalis L, cancer, leaf extract, rat | ||
| مراجع | ||
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