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Design of a Resonance Rayleigh Scattering Technique using PbS QDs-Gutathione Nanocomposite for Epinephrine drug Detection in Real samples | ||
| Iranian Journal of Analytical Chemistry | ||
| دوره 12، شماره 1 - شماره پیاپی 23، خرداد 2025، صفحه 64-74 اصل مقاله (1.2 M) | ||
| نوع مقاله: Full research article | ||
| شناسه دیجیتال (DOI): 10.30473/ijac.2025.75897.1326 | ||
| نویسندگان | ||
| Farzaneh Marahel* 1؛ Abdolmohsen Amouri1؛ Alireza Geramizadegan2؛ Mohammad Reza Asghariganjeh1 | ||
| 1Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran. | ||
| 2Department of Chemistry, Dashtestan Branch, Islamic Azad University, Dashtestan, Iran. | ||
| چکیده | ||
| In this study, a description of spectrofluorometer method for the measure of epinephrine (EP) drug in urine and blood samples using lead sulfide (PbS) quantum dots via glutathione nanocomposite as a sensor using a resonance Rayleigh scattering (RRS) technique. The sensor was characterized using FTIR, XRD, SEM, and TEM. The scattering intensity (∆IRRS) signal was detected by a fluorescence detector at λ(ex) = 325 nm. Under the optimum conditions, the calibration plot is linear in the (EP) drug concentration range of (0.050‒200.0 ng L-1). The standard deviations of (1.2 %), detection limit (LOD) of the method (0.015 ng L-1) and quantification (LOQ) of the method (0.044 ng L-1) in time 50 s, 325 nm for sensor level response PbS QDs-glutathione nanocomposite with (96 %) confidence evaluated. Moreover, a PbS QDs-glutathione nanocomposite sensor with RRS technique for the analysis of (EP) drug in urine and blood samples with high % recoveries (94.0 -99.2 %), low % RSD values (< 3 %) was used. This method offers a reliable approach for detecting various drugs in clinical and pharmaceutical settings. | ||
| کلیدواژهها | ||
| Epinephrine drug؛ Glutathione؛ PbS quantum dots؛ Sensor؛ Resonance Rayleigh Scattering | ||
| عنوان مقاله [English] | ||
| طراحی تکنیک پراکندگی رزونانس ریلی با استفاده از نقاط کوانتومی سولفید سرب با پوشش گلوتاتیون برای تشخیص داروی اپی نفرین در نمونههای حقیقی | ||
| نویسندگان [English] | ||
| فرزانه مراحل1؛ عبدالمحسن عموری1؛ علیرضا گرامی زادگان2؛ محمد رضا اصغری گنجه1 | ||
| 1گروه شیمی واحد امیدیه، دانشگاه آزاد اسلامی، امیدیه، ایران. | ||
| 2گروه شیمی واحد دشتستان، دانشگاه آزاد اسلامی، دشتستان، ایران. | ||
| چکیده [English] | ||
| در این مطالعه، طراحی یک تکنیک پراکندگی رزونانس ریلی (RRS) با استفاده از نقاط کوانتومی سولفید سرب با پوشش گلوتاتیون به عنوان حسگر تشخیص داروی اپی نفرین در نمونههای واقعی اختصاص داده شد. تکنیک های مختلفی از جمله FTIR، XRD، SEM و TEM برای مشخص کردن سنسور استفاده شد. سیگنال شدت پراکندگی (IRRS∆) توسط یک آشکارساز فلورسانس درطول موج 325 نانومتر شناسایی شد. تحت شرایط بهینه، نمودار کالیبراسیون در محدوده غلظت داروی اپی نفرین (0/050 تا 200/0 نانوگرم در لیتر) خطی است. انحراف استاندارد نسبی (1/2± درصد)، و حد تشخیص (LOD) روش 0/015 نانوگرم در لیتر، و مقدار کمی سازی (LOQ) روش 0/044 نانوگرم در لیتر در زمان 50 ثانیه و طول موج 325 نانومتر برای پاسخ سطح سولفید سرب با پوشش گلوتاتیون با (96/0 درصد) اطمینان ارزیابی شد. علاوه بر این، از یک حسگر نقاط کوانتومی سولفید سرب با پوشش گلوتاتیون با تکنیک پراکندگی رزونانس رایلی برای آنالیز داروی اپی نفرین در نمونههای ادرار و خون با درصد بازیابی بالا (94/0 تا 99/2 درصد) و درصد RSD پایین (< 3/0 درصد) استفاده شد. این روش یک رویکرد قابل اعتماد برای تشخیص داروهای مختلف در محیطهای بالینی و دارویی ارائه میدهد. | ||
| کلیدواژهها [English] | ||
| اپی نفرین, گلوتاتیون, نقاط کوانتومی سولفید سرب, حسگر, پراکندگی رزونانس ریلی | ||
| مراجع | ||
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