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Comparative Electrochemical Study of Ferrocene and UiO-66-NH2 Metal–Organic Framework Modified Glassy Carbon Electrode With/Without Reduced Graphene Oxide for Sensitive Determination of Hydroxychloroquine | ||
| Iranian Journal of Analytical Chemistry | ||
| دوره 11، شماره 2 - شماره پیاپی 22، آذر 2024، صفحه 211-222 اصل مقاله (1.51 M) | ||
| نوع مقاله: Full research article | ||
| شناسه دیجیتال (DOI): 10.30473/ijac.2026.77002.1333 | ||
| نویسندگان | ||
| Abdolhamid Hatefi-Mehrjerdi* ؛ Hamid Reza Sobhi؛ Amir Hossein Esmaeili؛ Behzad Ahmadzadeh Fard | ||
| Department of Chemistry, Payam Noor University, P.O. Box 19395- 4697, Tehran, Iran. | ||
| چکیده | ||
| Hydroxychloroquine (HCQ) is a widely studied therapeutic agent that has garnered significant attention for its potential applications across a range of diseases. HCQ has since been investigated for its immunomodulatory and antiviral properties, making it a candidate in the management of autoimmune disorders as well as certain viral infections. The development of efficient electrochemical sensors for accurate HCQ measurement is crucial for clinical and pharmaceutical applications. This study presents a comprehensive comparative electrochemical investigation of glassy carbon electrode (GCE) modified with ferrocene (FC) and UiO-66-NH2 metal–organic frameworks (MOF), with and without reduced graphene oxide (rGO), for the sensitive detection of HCQ. FC and MOF incorporated with rGO to enhance their electrochemical properties. The fabricated HCQ sensor, with three wide linear ranges (1-50 nM, 50-1000 nM, and 1-100 μM), high sensitivity (0.265 μA nM−1, 0.032 μA nM−1, and 0.517 μA μM−1), and low detection limit (0.215 nM), was applied successfully for the analysis of real human blood serum and urine samples. | ||
| کلیدواژهها | ||
| Ferrocene؛ Metal–Organic Framework؛ Reduced Graphene Oxide؛ Sensitive Electrochemical Detection؛ Hydroxychloroquine | ||
| عنوان مقاله [English] | ||
| مطالعه الکتروشیمیایی مقایسهای الکترود کربن شیشهای اصلاحشده با فروسن و چارچوبهای فلزی–آلی UiO-66-NH2 با/بدون گرافن اکسید کاهشیافته برای تعیین حساس هیدروکسیکلروکین | ||
| نویسندگان [English] | ||
| عبدالحمید هاتفی مهرجردی؛ | ||
| عضو هیئت علمی پیام نور دلیجان | ||
| چکیده [English] | ||
| هیدروکسیکلروکین (HCQ) یک عامل درمانی پرمطالعه است که توجه زیادی را به دلیل کاربردهای بالقوه آن در طیف وسیعی از بیماریها به خود جلب کرده است. HCQ به دلیل خواص ایمنیتعدیلکننده و ضدویروسی مورد بررسی قرار گرفته و بهعنوان گزینهای در مدیریت اختلالات خودایمنی و برخی عفونتهای ویروسی مطرح شده است. توسعه حسگرهای الکتروشیمیایی کارآمد برای اندازهگیری دقیق HCQ در کاربردهای بالینی و دارویی اهمیت فراوانی دارد. این مطالعه یک بررسی جامع و مقایسهای الکتروشیمیایی از الکترود کربن شیشهای (GCE) اصلاحشده با فروسن (FC) و چارچوبهای فلزی–آلی UiO-66-NH2 (MOF)، با و بدون گرافن اکسید کاهشیافته (rGO)، برای آشکارسازی حساس HCQ ارائه میدهد. FC و MOF همراه با rGO بهمنظور بهبود ویژگیهای الکتروشیمیایی آنها به کار گرفته شدند. حسگر ساختهشده برای HCQ با سه بازه خطی گسترده (1–50 نانومولار، 50–1000 نانومولار، و 1–100 میکرومولار)، حساسیت بالا (μA nM−1 ۲۶۵/۰، μA nM−1 032/0 و μA μM−1 517/0) و حد تشخیص پایین (215/0 نانومولار)، با موفقیت برای تجزیه نمونههای واقعی سرم خون و ادرار انسان مورد استفاده قرار گرفت. | ||
| کلیدواژهها [English] | ||
| فروسن, چارچوب فلزی–آلی, گرافن اکسید کاهشیافته, آشکارسازی الکتروشیمیایی حساس, هیدروکسیکلروکین | ||
| مراجع | ||
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آمار تعداد مشاهده مقاله: 40 تعداد دریافت فایل اصل مقاله: 29 |
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