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Determination of Mesalazine Using Ion Mobility Spectrometry in Pharmaceutical Samples | ||
| Iranian Journal of Analytical Chemistry | ||
| دوره 12، شماره 2، اردیبهشت 2026، صفحه 52-59 اصل مقاله (581.8 K) | ||
| نوع مقاله: Full research article | ||
| شناسه دیجیتال (DOI): 10.30473/ijac.2026.77204.1339 | ||
| نویسندگان | ||
| Negar Gholhovallahi1؛ Ali Sheibani* 2 | ||
| 1Department of Chemistry, Ya.C., Islamic Azad University, Yazd, Iran | ||
| 2IAU, Yazd branchDepartment of Chemistry, Ya.C., Islamic Azad University, Yazd, Iran | ||
| چکیده | ||
| Ion mobility spectrometry is an analytical technique with main advantages such as high sensitivity, fast response and simplicity. The purpose of this work was to determine of mesalazine in different pharmaceutical samples using ion mobility spectrometry with a positive corona ionization source. After obtaining the best instrumental parameters (injection temperature: 230 ºC, cell temperature: 180 ºC, drift voltage: 6800 V, corona voltage: 2400 V, flow rate of drift gas: 600 mL/min and flow rate of carrier gas: 300 mL/min) the linear dynamic range was 1.0–70.0 ng with a determination coefficient, R2=0.9881. The relative standard deviation values were lower than 6.0% (n=5) for the examined range (10.0–60.0 ng) of the drug. The limit of detection and limit of quantitation were 0.3 ng and 1.0 ng, respectively. The capability of the developed method was evaluated for the determination of mesalazine in tablet, capsule, and suppository as pharmaceutical samples. Satisfactory recovery results were obtained in the range of 98.0–103.8%. | ||
| کلیدواژهها | ||
| Ion mobility spectrometry؛ Mesalazine؛ Pharmaceutical samples؛ Tablet؛ Capsule؛ Suppository | ||
| عنوان مقاله [English] | ||
| اندازه گیری مزالازین با روش طیف سنجی تحرک یونی در نمونه های دارویی | ||
| نویسندگان [English] | ||
| نگار قلهواللهی1؛ علی شیبانی2 | ||
| 1بخش شیمی، واحد یزد، دانشگاه آزاد اسلامی، یزد، ایران | ||
| 2بخش شیمی، واحد یزد، دانشگاه آزاد اسلامی، یزد، ایران | ||
| چکیده [English] | ||
| طیفسنجی تحرک یونی یک تکنیک تجزیهای با مزایای اصلی مانند حساسیت بالا، پاسخ سریع و سادگی است. هدف از این کار، تعیین میزان مزالازین در نمونههای دارویی مختلف با استفاده از طیفسنجی تحرک یونی مجهز به منبع یونش کرونا با قطبیت مثبت بود. پس از دستیابی به بهترین پارامترهای دستگاهی (دمای تزریق: °C ۲۳۰ ، دمای سل: °C ۱۸۰، ولتاژ شناوری: V۶۸۰۰، ولتاژ کرونا: V۲۴۰۰، سرعت جریان گاز شناوری: mL/min۶۰۰ و سرعت جریان گاز حامل: mL/min۳۰۰)، محدوده خطی دینامیکی 0/1 تا ng 0/70 با ضریب تعیین 9881/0 R² =به دست آمد. مقادیر انحراف استاندارد نسبی برای محدوده بررسی شده دارو (0/10 تا ng 0/60) کمتر از 6 درصد (n=5) بود. حد تشخیص و حد تعیین روش به ترتیب 3/0 و ng 0/1 محاسبه شد. قابلیت روش توسعه یافته برای تعیین مزالازین در نمونههای قرص، کپسول و شیاف ارزیابی شد که نتایج بازیابی رضایتبخشی در محدوده 0/98 تا 8/103 درصد به دست آمد. | ||
| کلیدواژهها [English] | ||
| طیف سنجی تحرک یونی, مزالازین, نمونه های دارویی, قرص, کپسول, شیاف | ||
| مراجع | ||
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آمار تعداد مشاهده مقاله: 12 تعداد دریافت فایل اصل مقاله: 10 |
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