پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 49 |
| تعداد شمارهها | 1,324 |
| تعداد مقالات | 11,459 |
| تعداد مشاهده مقاله | 24,542,558 |
| تعداد دریافت فایل اصل مقاله | 16,410,116 |
ارتباط T3 Resin Uptak با پارامترهای لیپیدی سرم در گاوهای هلشتاین بهظاهر سالم | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| دوره 14، شماره 2 - شماره پیاپی 54، مهر 1404، صفحه 9-17 اصل مقاله (1.16 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2026.76844.2024 | ||
| نویسندگان | ||
| علی شعبانی بزمین آبادی1؛ بهنام پدرام1؛ سیده ام البنین قاسمیان* 2 | ||
| 1گروه دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران | ||
| 2گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| چکیده | ||
| زمینه و هدف: شاخصهای سرمی بهطور گسترده در تشخیص بیماریهای مختلف مورداستفاده قرار میگیرند. با دانستن سطح آنها، میتوان اطلاعات ارزشمندی در مورد کاهش یا افزایش این شاخصها بهدست آورد. این مطالعه به بررسی رابطه بین T3 Resin Uptake و پروفایل لیپیدی سرم خون گاوهای هلشتاین به ظاهر سالم پرداخت. روش پژوهش: مطالعه حاضر یک پژوهش بنیادی تحلیلی بود که روی 120 گاو هلشتاین صورت گرفت. نمونهها از دامداری مهدشت شهرستان ساری، استان مازندران انتخاب شدند. جهت انجام آزمایش مقدار ۵ سیسی خون محیطی از نمونهها اخذ شد. برای سنجش درصد سرمی Resin uptake T3 از روش الایزا استفاده شد. پروفایل لیپیدی از نظر سطح سرمی سرمی Resin uptake T3 مورد ارزیابی قرار گرفت. نتایج: بهطور کلی، 120 گاو هلشتاین (77 مورد ماده و 43 مورد نر) با میانگین سنی نمونه موردبررسی 08/1±85/3 سال وارد این مطالعه شدند. ترییدوتیرونین تنها در 1/4 درصد (5 مورد) از موارد غیرنرمال بالا یا پایین بود. بین ترییدوتیرونین با کلسترول تام (06/0=r، 45/0=P)، تریگلیسیرید (04/0=r، 61/0=P)،LDL (06/0-=r، 51/0=P)، HDL (2/0-=r، 77/0=P) و VLDL(05/0=r، 55/0=P) همبستگی مشاهده نشد. میزان ترییدوتیرونین (38/2-=Z، 01/0=P) و کلسترول (81/2=t، 006/0=P) بهطور معنیداری در حیوانات ماده پایینتر از نمونههای نر بود. فاکتورهای ترییدوتیرونین و پروفایل چربی تفاوتی از نظر سن نداشتند (05/0<P). نتیجهگیری: این مطالعه نشان داد که ارتباط مستقیمی بین هورمون ترییدوتیرونین و پروفایل لیپیدی سرم گاوهای موردبررسی وجود ندارد. | ||
| کلیدواژهها | ||
| تیروئید؛ ترییدوتیرونین؛ پروفایل لیپیدی؛ کلسترول | ||
| عنوان مقاله [English] | ||
| Association of T3 resin uptake with serum lipid parameters in clinically normal Holstein cows | ||
| نویسندگان [English] | ||
| Ali Shabani Bazmin Abadi1؛ Behnam Pedram1؛ Seyedeh Ommolbanin Ghasemian2 | ||
| 1Department of Veterinary medicine, Sho.C., Islamic Azad University, Shoushtar, Iran | ||
| 2Department of Veterinary, Be.C., Islamic Azad University, Behbahan, Iran | ||
| چکیده [English] | ||
| Background and Objective: Serum indices are widely utilized in diagnose various diseases. By knowing their levels, valuable information can be obtained when these indices either decrease or increase. This study investigated the relationship between T3 Resin uptake and serum lipid profiles in apparently healthy Holstein cows. Method: This basic analytical research included 120 Holstein cows (77 females and 43 bulls) from e Mahdasht livestock farm in Sari County, Mazandaran Province. For each test, 5 cc of peripheral blood was collected from the samples. The Serum Resin Uptake T3 was measured using the ELISA method. The serum lipid profile was evaluated concerning the Resin Uptake T3 levels. Results: Among the 120 Holstein cows (77 females, 43 males), the mean age was 3.85±1.08 years. Only 1.4% (5 cases) of the cows exhibited abnormal triiodothyronine levels. No significant correlation was found between Triiodothyronine and total cholesterol (r=0.06, P=0.45), triglycerides (r=0.04, P=0.61), LDL (r=-0.06, P=0.51), HDL (r=-0.2, P=0.77), or VLDL (r=0.05, P=0.55). Female animals had significantly lower Triiodothyronine (Z=-2.38, P=0.01) and cholesterol (t=2.81, P=0.006) levels compared to males. There were no age-related differences in Triiodothyronine and lipid profile factors (P<0.05). Conclusion: This study concluded that there was no direct relationship between Triiodothyronine levels and serum lipid profile in the examined cows. | ||
| کلیدواژهها [English] | ||
| Thyroid, Triiodothyronine, Lipid Profile, Cholesterol | ||
| مراجع | ||
|
Akaberi, A., Ghanbari, R., & Golshan, A.-R. (2018). The Relationship between subclinical hypothyroidism with Parathyroid hormone levels and Lipid profiles in patients on dialysis. Iranian Journal of Nursing Research, 12(6), 45-50 .http://doi.org/ 10.21859/ijnr-12066
Al-Tonsi, A., Abdel-Gayoum, A., & Saad, M. (2004). The secondary dyslipidemia and deranged serum phosphate concentration in thyroid disorders. Experimental and molecular pathology, 76(2), 182-187.http://doi.org/ 10.1016/j.yexmp.2003.10.005
Asvold, B. O., Vatten, L. J., Nilsen, T. I., & Bjøro, T. (2007). The association between TSH within the reference range and serum lipid concentrations in a population-based study. The HUNT Study. European journal of endocrinology, 156(2), 181-186. http://doi.org/ 10.1530/eje.1.02334
Bolton, J., Sanders, J., Oda, Y., Chapman, C., Konno, R., Furmaniak, J., & Rees Smith, B. J. C. c. (1999). Measurement of thyroid-stimulating hormone receptor autoantibodies by ELISA. 45(12), 2285-2287. .http://doi.org/10.1093/clinchem/45.12.2285
Bremner, A. P., Feddema, P., Leedman, P. J., Brown, S. J., Beilby, J. P., Lim, E. M.,… Walsh, J. P. (2012). Age-related changes in thyroid function: a longitudinal study of a community-based cohort. The Journal of Clinical Endocrinology, 97(5), 1554-1562. http://doi.org/10.1210/jc.2011-3011
Chakravarthy, V., & Ejaz, S. (2023). Thyroxine-binding globulin deficiency. In StatPearls [Internet]. StatPearls Publishing. http:// NCBI Bookshelf- StatPearls. NBK546603
Dinarvand, G., Veis Raygani, A., & Ghanbari, N. (2015). Correlation between Serum T3 Resin Uptake and Serum Lipid Profile. Medical Laboratory Journal, 9(1), 84-89. http://doi.org/10.18869/acadpub.mlj.9.1.84
Dinarvand GH, V.-R. A., Rezvani, A, Rahimi, Z., & Ghanbari, N. (2013). Relationship between serum levels of thyroid hormones and thyroid-stimulating hormone with components of serum lipid profile. Journal of Kermanshah University of Medical Sciences, 17(9), 2588-2570: http://(Indexing ID: e74340).
Donner, J. R., & Topor, L. S. (2021). Thyroid Studies. Endocrine Conditions in Pediatrics: A Practical Guide, 149-156. http://doi.org/ 10.1007/978-3-030-52215-5_19
Dunn, A., Duffy, C., Gordon, A., Morrison, S., Argűello, A., Welsh, M., & Earley, B. J. J. o. A. A. R. (2018). Comparison of single radial immunodiffusion and ELISA for the quantification of immunoglobulin G in bovine colostrum, milk and calf sera Oxford Academic - Journal of Animal Science. 46(1), 758-765. http://doi.org/10.1093/jas/skx021
Duntas, L. H., & Brenta, G. (2016). Thyroid hormones: a potential ally to LDL-cholesterol-lowering agents. Hormones, 15(4), 500-510.
Haghi, A. R., Solhjoo, M., & Tavakoli, M. H. (2017). Correlation between subclinical hypothyroidism and dyslipidemia. Iranian journal of pathology, 12(2), 106 Dunn, A., Duffy, C., Gordon, A., Morrison, S., Argűello, A., Welsh, M., & Earley, B. J. J. o. A. A. R. (2018). Comparison of single radial immunodiffusion and ELISA for the quantification of immunoglobulin G in bovine colostrum, milk and calf sera. 46(1), 758-765. http://doi.org/ 10.18869/acadpub.ijp.12.2.106
Hamad, D. S. (2020). Relation between Serum Lipids and Thyroid Hormones in Hypothyroidism Patients. Indian Journal of Forensic Medicine & Toxicology, 14(4), 4130-4134. http://doi.org/10.37506/ijfmt.v14i4.12282
Huang, X. J. F. i. E. (2025). Elevated total cholesterol in healthy adults mediates the association between impaired thyroid hormone sensitivity and hyperuricemia. Frontiers in Endocrinology, 16, 1625843. http://doi.org/10.3389/fendo.2025.1625843
Jung, K. Y., Ahn, H. Y., Han, S. K., Park, Y. J., Cho, B. Y., & Moon, M. K. (2017). Association between thyroid function and lipid profiles, apolipoproteins, and high-density lipoprotein function. Journal of clinical lipidology, 11(6), 1347-1353 http://doi.org/10.1016/j.jacl.2017.08.016
Kebamo, T. E., Tantu, A., Solomon, Y., & Walano, G. A. J. B. E. D. (2025). A comparative study on serum lipid levels in patients with thyroid dysfunction: a single-center experience in Ethiopia. 25(1), 47. http://doi.org/ 10.1186/s12902-025-01764-1
Liu, H., & Peng, D. (2022). Update on dyslipidemia in hypothyroidism: the mechanism of dyslipidemia in hypothyroidism. Endocrine Connections, 11(2). http://doi.org/10.1530/EC-21-0556
Maugeri, D., Santangelo, A., Barbagallo, P., Bonanno, M., Malaguarnera, M., Rizza, I.,…Panebianco, P. (1999). Thyroid hormones and lipid metabolism in a group of patients over seventy. European Review for Medical and Pharmacological Sciences, 3, 211-216. PMID: 10710825
Mortazavi S, A. A., Sajjadi, S. (2017). Study of the relationship between thyroid hormone levels (T3 and T4) and thyroid-stimulating hormone (TSH) with serum cholesterol (CH) and triglyceride (TG) levels in hospitalized patients Annual Research Congress of Medical Sciences Students in the East of the Country, gonabad.ac.ir
Mya, M. M., & Aronow, W. S. (2002). Subclinical hypothyroidism is associated with coronary artery disease in older persons. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 57(10), M658-M659 http://doi.org/10.1093/gerona/57.10.M658
Piechotta, M., Holzhausen, L., Araujo, M. G., Heppelmann, M., Sipka, A., Pfarrer, C.,Bollwein, H. (2014). Antepartal insulin-like growth factor concentrations indicating differences in the metabolic adaptive capacity of dairy cows. Journal of veterinary science, 15(3), 343. http://doi.org/10.4142/jvs.2014.15.3.343
Pires, J., Delavaud, C., Faulconnier, Y., Pomies, D., & Chilliard, Y. (2013). Effects of body condition score at calving on indicators of fat and protein mobilization of periparturient Holstein-Friesian cows. Journal of Dairy Science, 96(10), 6423-6439.http://doi. 10.3168/jds.2013-6804
Ritter, M. J., Amano, I., & Hollenberg, A. N. (2020). Thyroid hormone signaling and the liver. Hepatology, 72(2), 742-752 http://doi.org/. 10.1002/hep.31196
Rizos, C., Elisaf, M., & Liberopoulos, E. (2011). Effects of thyroid dysfunction on lipid profile. The Open Cardiovascular Medicine Journal, 5, 76. 10.2174/1874192401105010076
Sabatino, L., & Vassalle, C. J. B. (2025). Thyroid Hormones and Metabolism Regulation: Which Role on Brown Adipose Tissue and Browning Process Biomolecules, 15(3), 361 http://doi.org/10.3390/biom15030361
Šamanc, H., Stojić, V., Kirovski, D., Jovanović, M., Cernescu, H., & Vujanac, I. (2010). Thyroid Hormones Concentrations during the Mid‐Dry Period: An Early Indicator of Fatty Liver in Holstein‐Friesian Dairy Cows. Journal of thyroid research, 2010(1), 897602 http://doi.org/10.4061/2010/897602
Shahreza, F. D., Seifi, H. A., & Mohri, M. (2022). The relationship between body condition score, thyroxin, and health condition and serum energy indices, insulin like growth factor-1, and lipids profile over the transition period in Holstein dairy cows. Iranian journal of veterinary research, 23(2), 111. http://doi.org/ 10.22099/ijvr.2022.40871.5936
Si, S.-A., Lu, R.-N., & Zhang, G.-J. J. H. (2025). Association of the thyroid hormone sensitivity index with triglycerides in adolescents: a cross-sectional study. Frontiers, 1-11 http://doi.org/10.3389/fendo.2025.1616907
Sinha, R. A., & Yen, P. M. (2024). Metabolic Messengers: Thyroid Hormones. Nature metabolism, 6(4), 639-650. http://doi.org/10.1038/s42255-024-01019-2
Su, X., Peng, H., Chen, X., Wu, X., & Wang, B. (2022). Hyperlipidemia and hypothyroidism. Clinica Chimica Acta, 527, 61-70. 10.1016/j.cca.2021.12.016
Suhy, A., Hartmann, K., Papp, A. C., Wang, D., & Sadee, W. (2015). Regulation of cholesteryl ester transfer protein expression by upstream polymorphisms: reduced expression associated with rs247616. Pharmacogenetics and genomics, 25(8), 394-401. http://doi.org/ 10.1097/FPC.0000000000000147
Yan, F., Wang, Q., Lu, M., Chen, W., Song, Y., Jing, F.,… Bo, T. J. J. o. H. (2014). Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity. 61(6), 1358-1364 http://doi.org/ 10.1016/j.jhep.2014.07.023 | ||
|
آمار تعداد مشاهده مقاله: 1 |
||