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تأثیر تمرین تناوبی شنا با شدت بالا و مکمل‌دهی رسوراترول بر محتوای پروتئین‌های JNK3 و FOXO3a در بافت مغز موش‌های صحرایی سالمند | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| دوره 14، شماره 3 - شماره پیاپی 55، اسفند 1404، صفحه 1-11 اصل مقاله (1.1 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2026.76570.2020 | ||
| نویسندگان | ||
| کاووس عیدی وندی1؛ سیده ام البنین قاسمیان* 2 | ||
| 1گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| 2گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| چکیده | ||
| مقدمه: مطالعه حاضر با هدف تأثیر تمرین تناوبی شنا با شدت بالا و مکمل‌دهی رسوراترول بر محتوای پروتئین‌های JNK3 وFOXO3a در بافت مغز موش‌های صحرایی سالمند، صورت گرفت. روش پژوهش: پژوهش حاضر از نوع تجربی- بنیادی بود که روی 40 سر موش صحرایی نژاد ویستار سالمند که از مرکز نگهداری حیوانات دانشگاه علوم پزشکی شیراز تهیه شده بودند، صورت گرفت. نمونه به‌طور تصادفی به پنج گروه کنترل (8 سر)، تمرین (8 سر)، مکمل (8 سر)، تمرین+ مکمل (8 سر) و محلول (8 سر) تقسیم شدند. تمرین HIIT شنا به‌مدت شش هفته (14 نوبت 20 ثانیه‌ای شنا با 10 ثانیه استراحت بین هر نوبت) و مکمل رسوراترول روزانه 10 میلی‌گرم به‌ازای هر کیلوگرم وزن بدن در گروه‌های مداخله، صورت گرفت. یافتهها: یافتهها حاکی از وجود تفاوت معنی‌دار بین میانگین محتوای پروتئین‌های JNK3 و FOXO3a در گروه‌ها بود (0001/0P=). مقایسه دو به دو گروه‌ها نشان داد که محتوای پروتئین‌های JNK3 و FOXO3a بین جفت گروه‌های کنترل و مکمل، کنترل و تمرین، کنترل و تمرین+ مکمل، محلول و مکمل، محلول و تمرین، محلول و تمرین+ مکمل، مکمل و تمرین و همچنین مکمل و تمرین+ مکمل تفاوت معنیداری داشت (0/05>P). تفاوت معنیداری بین گروه تمرین و مکمل+ تمرین به لحاظ محتوای پروتئین‌های JNK3 (0/99<P) و FOXO3a (0/97=P) مشاهده نشد. بحث و نتیجه‌گیری: تمرین شنای تناوبی با شدت بالا و مکمل‌دهی رسوراترول منجر به کاهش محتوای پروتئین‌های JNK3 و FOXO3a در بافت مغز موش‌های صحرایی می‌شود | ||
| کلیدواژه‌ها | ||
| پروتئین JNK3؛ پروتئین FOXO3a؛ تمرین تناوبی با شدت بالا؛ بافت هیپوکمپ؛ مکمل رسوراترول | ||
| عنوان مقاله [English] | ||
| The Impact of High-Intensity Interval Swimming and Resveratrol Supplementation on JNK3 and FOXO3a Protein Levels in the Brain Tissue of Aged Rats | ||
| نویسندگان [English] | ||
| Kavous Eydivandi1؛ Seyedeh Ommolbanin Ghasemian2 | ||
| 1Department of Sport Physiology, Be.C., Islamic Azad University, Behbahan, Iran | ||
| 2Department of Veterinary, Be.C., Islamic Azad University, Behbahan, Iran | ||
| چکیده [English] | ||
| Background: This study aimed to examine the effects of high-intensity interval swimming training and resveratrol supplementation on the levels of JNK3 and FOXO3a proteins in the brain tissue of aged rats. Materials and Methods: This experimental study was conducted on 40 aged Wistar rats obtained from the Animal Care Center of Shiraz University of Medical Sciences. The rats were randomly assigned to five groups (n=8 per group): control, training, supplement, training + supplement, and solution. The training groups underwent high-intensity interval swimming for six weeks, consisting of 14 swimming bouts of 20 seconds each, with 10 seconds of rest between sessions. Rats in the supplement and training + supplement groups received a daily dose of resveratrol at 10 mg/kg body weight via gavage. Results: The results revealed a statistically significant difference in the mean levels of JNK3 and FOXO3a proteins among the groups (P=0.0001). Pairwise comparisons showed significant differences in protein levels between the following group pairs: control vs. supplement, control vs. training, control vs. training+ supplement, solution vs. supplement, solution vs. training, solution vs. training+ supplement, supplement vs. training, and supplement vs. training+ supplement (P<0.05). However, no significant difference was observed between the training and training+ supplement groups regarding JNK3 (P= 0.99) and FOXO3a (P= 0.97) protein levels. Conclusion: High-intensity interval swimming and resveratrol supplementation independently reduce the levels of JNK3 and FOXO3a proteins in the brain tissue of aged rats, suggesting potential neuroprotective effects. | ||
| کلیدواژه‌ها [English] | ||
| JNK3 protein, FOXO3a protein, High-intensity interval training, Hippocampal tissue, Resveratrol supplementation | ||
| مراجع | ||
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