Effect of Hydroalcoholic Extract of Allium hirtifolium on some Biochemical Factors Following Gentamicinin in Mice | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| Article 2, Volume 3, Issue 2, March 2015, Pages 11-20 PDF (754.3 K) | ||
| Document Type: Article | ||
| Authors | ||
| M. S. ABEDSAEEDI11; H. GHODRATI AZADI* 2 | ||
| 1MSc. Student, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| 2Assistant Professor, Department of Basic Sciences, Faculty of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad, Iran | ||
| Abstract | ||
| Some studies on the toxicity of gentamicin-induced oxygen metabolites involved would beknow. On the one hand due to the antioxidant properties of garlic aim of this study was to investigate the effect of shallot extract (Allium hirtifolium Boiss) after gentamicin administration in mice. The experimental study on 32 mice weighing 30±5 in 4 groups each 8 mice, 1 or control group receiving distilled water (0.7 ml), Group 2: treated with gentamicin dose 80 mg/kg to create Hepatic and renal impairment and groups 3 and 4, respectively, shallot extract in doses of 40 mg/kg and of 80 mg/kg with gentamicin (80 mg/kg) performed. Experimental period in all groups was 10 days. At the end of the experiment after 24 hours from the last injection, biochemical parameters, urea, creatinine, uric acid, alkaline phosphatase, lactate dehydrogenase, aspartate amino transferase and alanine amino transferase were measured by routine enzymatic and laboratory methods. Administration of gentamicin combined with shallots (40 mg/kg) decreased alkaline phosphatase activity (92±40.36) compared with group 2 (158.73±40.36) and Group 1 (157.40±44.07) (p0.05). Results showed that shallot extract may reduce biochemical factors resulting from the use of gentamicin. | ||
| Keywords | ||
| Allium hirtifolium; Gentamicin; Biochemical Parameters; Antioxidant Effects | ||
| References | ||
|
Abdel-Naim A (1999) Protective effect of vitamin E and probacol against gentamicin induced nephrotoxicity in rat. Pharmacol Res. 40: 183-187.
Alarifi S, Al-Doaiss A, Alkahtani S, Al-Farraj SA (2012) Blood chemical changes and renal histological alterationsinduced by gentamicin in rats. Saudi Journal of Biological Sciences. 19: 103-110.
Alkhtani S, Alarifi Saud A, Doaiss A, Abdullah A (2009) Detection of apoptotsis induced by gentamicin in rat hepatocytes.Int. J. Zoolog. Res. 5: 161-170.
Banerjee SK, Maulik M (2012) Garlic-induced alteration in rat liver and kidney morphology and associated changes in endogenous antioxidant status. Food and Chemical Toxicology. 39(8): 793-797.
ChaithradhyuthiGayathri S, Sowmya PS, Shwetha B, Gowri S, Rama Bhat P, Nagasampige H, Rao BR (2009) Evaluation of the antioxidant and antimicrobial properties of some members of Allium. J. Environ. Agric. Food Chem. 8: 345-350
Clerici WJ, Hensley K, DiMartino DL, Butter¢eld DA (1996) Direct detection of ototoxicant-induced reactive oxygen speciesgeneration in cochlear explants. Hear. Res. 98: 116-124.
Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Paola R., Britti D (2002) A role for superoxide in gentamicin- mediated nephropathy in rats. Eur j pharmacol. 450: 67-76.
El-Ashmawy H.M, El-Nahas EF, Salama OM (2006) Grape seedextract prevents gentamicin-induced nephrotoxicity and genotoxi-city in bone marrow cells of mice. Basic Clin. Pharmacol. Toxicol. 99(3): 230-236.
Ender H, Alev G et al (2013) The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model International Journal of Endocrinology Article ID 313528, http://dx.doi.org/10.1155/2013/313528
Geng Z, Rong Y, Lau BH (1997) S-Allyl cysteine inhibits activation of nuclear factor kappa B in human T cells. Free Radic. Biol. Med. 23:345-350.
Ghahremani-majd H, Dashti F (2012) Antioxidant and antimicrobial activities of Iranian mooseer (Allium hirtifoliumBoiss) populations.Horticulture Environmentand Biotechnology. 53(2): 116-122.
Ghodrati Azadi H, Ghaffari SM, Riazi GH, Ahmadian S, Vahedi F (2008) Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cytotechnology. 56(3): 179-185.
Hojat Ghahremani M, Farshad D , Dara D , Hasan M , Javad H , Mahmood E (2012) Antioxidant and antimicrobial activities of Iranian mooseer (Allium hirtifolium Boiss) populations Horticulture, Environment, and Biotechnology. 53(2): 116-122.
Hickman JA, Boyle CC (1997) Apoptosis and cytotoxins. Br.Med. Bull. 53: 632-643.
Hirose K, Hockenbery DM, Rubel EW (1997) Reactive oxygenspecies in chick hair cells after gentamicin exposure in vitro. Hear.Res. 104, 1-14.
Inoue S, Kawanishi S (1995) Oxidative DNA damage induced by simultaneous generation of nitric-oxide and superoxide. FEBS let. 371: 86-88.
Kim KM,Chun SB, Koo MS, Choi WJ, Kim TW,Kwon YG, Chung HT, Billiar TR, Kim YM (2001) Differentialregulation of NO availability from macrophages and endothelialcells by the garlic component S-allyl cysteine. Free Radic. Biol .Med. 30:747–756.
Maldonado P, Barrera D, Rivero I, Mata R, Medina O, Hernandez R (2003) Antioxidant S-allylcysteine prevents gentamicin-induced oxidative stress and renal damage. Free Radic Biol Med. 35: 317-24.
Manfred K,EberhardT (2001) Reactive oxygen metabolites. United States of America: CRC Press.
Mingeot-Leclercq MP, Tulkens PM (1999) Aminoglycosides: nephrotoxicity,” Antimicrobial Agents and Chemotherapy. vol. 43, 5: 1003–1012.
Nasri H, Rafieian-Kopaei M (2014) Preventive and Curative Effect of Garlic on Nephrotoxic Effect of Gentamicin in Rat. J BabolUniv Med Sci. 16(2): pp: 42-48.
Neyagawa S, Kasuga S, Matsuura H (1989) Prevention of Liver Damage by Aged Garlic Extract and Its Components in Mice. Phytotherapy Research. 3(2): 50-53.
Numagami Y, Ohnishi ST (2001) S-allylcysteine inhibits free radical production, lipid peroxidation and neuronal damage in rat brain ischemia. JNutr. 131:1100S-1105S.
Omidi A, Torabi Z, Hassanpoorfard M, Zardast M (1994) Evaluation of protective effect of the hydro alcoholic extract of Crocus sativus petals on preventing of gentamicin induced peliosishepatis and hepatic telangiectasis in rats. Journal of Birjand University of Medical Sciences. 19 (4): 455-462.
Paskaloglu K, Arbak S (2002) Melatonin protects against gentamicin-induced nephrotoxicity in rats. J Pineal Res. 32: 231-236.
Pedraza J, Gonzalez A, Maldonado D, Barrera D, Medina O, Hernandez R (2003) disulfide ameliorates gentamicin-induced oxidative stress and nephropathy in rats. Eur J Pharmacol. 18: 71-8.
Ra¡ray M, Cohen GM (1997) Apoptosis and necrosis in toxicol-ogy: a continuum or distinctmodes of cell death?.Pharmacol.Ther. 75: 153-177.
Stojilkovic N, Stojilkovic M, Randjelovic p, Veljkovic s, Mihailovic,D (2012) Cytoprotective effect of vitamin C against gentamaicin-induced acute kidney injury in rat. Exprimental and toxicoligic pathology. 64:69-74.
Yang C, Du X, Han Y (1995) Renal cortical mitochondria are the source of oxygen free radicals enhanced by gentamicin. RenFail. 17: 21-26.
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