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Josefa, Paat, Lauro, figueroa, Maria, Lopez, Lenin, Hau, Francisco, Diaz, Elodia, Garcia, Eduardo, Pool, Marcela, rosas, Virginia, Mateu. (1397). Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools. فصلنامه علمی ـ پژوهشی زیست فناوری گیاهان زراعی, 6(Issue 3, pp. 218-324), 256-265.
Paat Josefa; figueroa Lauro; Lopez Maria; Hau Lenin; Diaz Francisco; Garcia Elodia; Pool Eduardo; rosas Marcela; Mateu Virginia. "Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools". فصلنامه علمی ـ پژوهشی زیست فناوری گیاهان زراعی, 6, Issue 3, pp. 218-324, 1397, 256-265.
Josefa, Paat, Lauro, figueroa, Maria, Lopez, Lenin, Hau, Francisco, Diaz, Elodia, Garcia, Eduardo, Pool, Marcela, rosas, Virginia, Mateu. (1397). 'Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools', فصلنامه علمی ـ پژوهشی زیست فناوری گیاهان زراعی, 6(Issue 3, pp. 218-324), pp. 256-265.
Josefa, Paat, Lauro, figueroa, Maria, Lopez, Lenin, Hau, Francisco, Diaz, Elodia, Garcia, Eduardo, Pool, Marcela, rosas, Virginia, Mateu. Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools. فصلنامه علمی ـ پژوهشی زیست فناوری گیاهان زراعی, 1397; 6(Issue 3, pp. 218-324): 256-265.

Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools

Iranian Chemical Communication
مقاله 4، دوره 6، Issue 3, pp. 218-324، پاییز 2018، صفحه 256-265  XML اصل مقاله (597 K)
نوع مقاله: Original Research Article
نویسندگان
Paat Josefa1؛ figueroa Lauro 1؛ Lopez Maria2؛ Hau Lenin2؛ Diaz Francisco3؛ Garcia Elodia2؛ Pool Eduardo2؛ rosas Marcela4؛ Mateu Virginia5
1University Autonomous of Campeche
2University Autonomous of campeche
3IPN
4Universidad Veracruzana
5Universidad veracruzana
چکیده
The aim of this study was to synthesize a new oxetan-phenyltetrahydropyridazine-3,6-dione derivative (compound 6) using with different techniques. The first method was achieved by the preparation of a phenylhydrazine derivative (2) using three components system (3,17-aldol-estradiol, phenylhydrazine, 5-hexyn-3-ol) in presence of Copper(II). Then, 2 Was reacted with tert-butyldimethylsilyl chloride to form the compound 3 (trimethylbutan-silyloxy-steroid-hydrazine). Following, a pyridazine derivative (4); was prepared by the reaction of 3 with succinic acid using boric as catalyst. The compound 4 was reacted with hydrofluoric acid to form the a tetrahydropyridazine-3,6-dione (5). Finally, the preparation of 6 was carried out by the reaction of 5 with CopperII. Spectroscopy analyses NMR was used to confirm the chemical structure of compounds. In conclusion, in this study a facile method to synthesis of an oxetan-phenyltetrahydropyridazine-3,6-dione is reported.
کلیدواژه‌ها
Steroid؛ derivative؛ phenylhydrazine؛ tetrahydropyridazine؛ oxetan
مراجع
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