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Preparation of an oxetan-phenyltetrahydropyridazine-3,6-dione derivative using some chemistry tools | ||
Quarterly Iranian Chemical Communication | ||
مقاله 4، دوره 6، Issue 3. pp. 218-320، پاییز 2018، صفحه 256-265 اصل مقاله (597 K) | ||
نوع مقاله: Original Research Article | ||
نویسندگان | ||
Paat Josefa1 ؛ figueroa Lauro ![]() | ||
1University Autonomous of Campeche | ||
2University Autonomous of campeche | ||
3IPN | ||
4Universidad Veracruzana | ||
5Universidad veracruzana | ||
چکیده | ||
The aim of this study was to synthesize a new oxetan-phenyltetrahydropyridazine-3,6-dione derivative (compound 6) using with different techniques. The first method was achieved by the preparation of a phenylhydrazine derivative (2) using three components system (3,17-aldol-estradiol, phenylhydrazine, 5-hexyn-3-ol) in presence of Copper(II). Then, 2 Was reacted with tert-butyldimethylsilyl chloride to form the compound 3 (trimethylbutan-silyloxy-steroid-hydrazine). Following, a pyridazine derivative (4); was prepared by the reaction of 3 with succinic acid using boric as catalyst. The compound 4 was reacted with hydrofluoric acid to form the a tetrahydropyridazine-3,6-dione (5). Finally, the preparation of 6 was carried out by the reaction of 5 with CopperII. Spectroscopy analyses NMR was used to confirm the chemical structure of compounds. In conclusion, in this study a facile method to synthesis of an oxetan-phenyltetrahydropyridazine-3,6-dione is reported. | ||
کلیدواژگان | ||
Steroid؛ derivative؛ phenylhydrazine؛ tetrahydropyridazine؛ oxetan | ||
آمار تعداد مشاهده مقاله: 75 تعداد دریافت فایل اصل مقاله: 44 |
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