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اثر تمرین هوازی همراه با ویتامین C بر آنزیمهای کبدی و فاکتورهای TAC و MDA در موشهای صحرایی مبتلا به آلزایمر | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| دوره 12، شماره 1 - شماره پیاپی 45، شهریور 1402، صفحه 33-43 اصل مقاله (306.12 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2023.67998.1909 | ||
| نویسندگان | ||
| آسیه سید1؛ فاطمه حرفشنو1؛ مریم خراسانینژاد1؛ ام البنین قاسمیان* 2؛ حسن جوهری1 | ||
| 1گروه فیزیولوژی ورزشی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| 2گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| چکیده | ||
| بیان مساله: کبد، عضو اصلی مسئول کنترل متابولیک و سم زدایی متابولیک است که به طور قابلتوجهی به پاکسازی پلاکهای بتا آمیلوئید کمک میکند. اختلال عملکرد کبدی ممکن است خطر ابتلا به آلزایمر را افزایش دهد. هدف: بررسی اثر یک دوره تمرین هوازی همراه با ویتامین C بر آنزیمهای کبدی و ظرفیت آنتیاکسیدانی در موشهای صحرایی آلزایمری مواد و روشها: مطالعه حاضر یک تحقیق تجربی و بنیادی با پس آزمون و گروه کنترل بود که روی 35 سر موش صحرایی نر نژاد اسپراگو-داولی بین 14 تا 16 ماه انجام شد. نمونهها، به طور تصادفی به 5 گروه (7 سر در هر گروه) شامل 1) آلزایمر، 2) سالم، 3) تمرین، 4) ویتامین C و 5) تمرین + ویتامین C تقسیم شدند. تمرین به مدت هشت هفته، سه جلسه در هفته تمرین هوازی بر نوار گردان پرداختند. پروتئین تام موجود در بافت کبد برای اندازهگیری TAC، MDA، سطوح آلانین آمینوترانسفراز (AST)، آلکانین فسفاتاز (AST) و آسپارتات آمینوترانسفراز (AST) مورد سنجش قرار گرفت. یافتهها: مقادیر AST، ALT و ALP، MDA و TAC در گروه کنترل مبتلا به بیماری آلزایمر به طور معنیداری بیشتر از گروه کنترل سالم بود (05/0>P). پس از مداخله، AST، ALT و ALP در گروههای تمرین و مصرف مکمل ویتامیل C به طور معنی داری کمتر از گروههای عدم تمرین بود (001/0=P). نتیجهگیری: تمرین هوازی و مکمل دهی ویتامین C در بهبود فاکتورهای کبدی در موشهای صحرایی مبتلا به آلزایمر موثر است. با اینحال، تاثیری بر میزان MDA و TAC ندارد. | ||
| کلیدواژهها | ||
| تمرین هوازی؛ ویتامین C؛ آنزیمهای کبدی؛ بیماری آلزایمر | ||
| عنوان مقاله [English] | ||
| Effect of Aerobic Exercise With Vitamin C on Liver Enzymes and Total Antioxidant Capacity and Malondialdehyde in Rats with Alzheimer's Disease | ||
| نویسندگان [English] | ||
| Asiye Seyyed1؛ Fatemeh Harfsheno1؛ Maryam Khorasani nejad1؛ omolbanin ghasemian2؛ Hassan Johari1 | ||
| 1Department of Sport physiology, Behbahan Branch, Islamic Azad University, Behbahan, Iran | ||
| 2Department of Veterinary, Behbahan Branch, Islamic Azad University, Behbahan, Iran | ||
| چکیده [English] | ||
| Statement of the problem: The liver is the main organ responsible for metabolic control and metabolic detoxification, which significantly contributes to the clearance of beta-amyloid plaques. Aim: The present study aimed to investigate the effect of aerobic exercise with a supplement of vitamin C on liver enzymes and total antioxidant capacity (TAC) values in rats with Alzheimer's disease. Materials and Methods: This was an experimental and fundamental research with a post-test and a control group conducted on 35 aged male Sprague-Dawley rats. The samples were randomly assigned to five groups (7 cases in each group), including 1) Alzheimer, 2) the healthy, 3) the exercise group, 4) the vitamin C, and 5) the exercise+vitamin C group. Aerobic exercise was continued for eight weeks, Total protein in liver tissue was measured to assess TAC, Malondialdehyde (MDA, alanine aminotransferase (AST), alkane phosphatase (AST), and aspartate aminotransferase (AST) levels. Results: The values of AST, ALT and ALP, MDA, and TAC in the control group with Alzheimer's disease were significantly higher than those in the healthy control group (P<0.05). After the intervention, AST, ALT, and ALP in the exercise and vitamin C supplement groups were significantly lower than in the non-exercise groups (P=0.001). Conclusion: Aerobic exercise and vitamin C supplementation are effective in improving liver factors in rats with Alzheimer's disease; however, they have no therapeutic effect on MDA and TAC levels in rats with Alzheimer's. | ||
| کلیدواژهها [English] | ||
| Aerobic Exercise, Alzheimer's Disease, Liver Enzymes, Vitamin C | ||
| مراجع | ||
|
Abbsidarehbidi, M., & Bambaeichi, E. (2019). Comparison of the effects of aerobic training with vitamin C and estradiol on markers of the liver among ovariectomized and normal rats. Journal of Ilam University of Medical Sciences, 27(2), 198-209.
Ahmadi, M., Rahmani, M., & Khalili Najafabadi, M. (2022). The effect of sprint interval training on plasma liver enzymes, liver tissue total-antioxidant-capacity and malondialdehyde in male rats. Daneshvar Medicine, 30(2), 50-60.
Aliev, G., Obrenovich, M. E., Reddy, V. P., Shenk, J. C., Moreira, P. I., Nunomura, A., ... Perry, G. (2008). Antioxidant therapy in Alzheimer’s disease: theory and practice. Mini reviews in medicinal chemistry, 8(13), 1395.
Beyranvand, M., & Rahmani, M. (2022). The effect of sprint interval training on lipid peroxidation, total antioxidant capacity and heart tissue fibrosis in healthy rats. Daneshvar Medicine, 30(1), 84-94.
Bherer, L., Erickson, K. I., & Liu-Ambrose, T. (2013). Physical exercise and brain functions in older adults. In (Vol. 2013): Hindawi.
Chang, C.-K., Huang, H.-Y., Tseng, H.-F., Hsuuw, Y.-D., & Tso, T. K. (2007). Interaction of vitamin E and exercise training on oxidative stress and antioxidant enzyme activities in rat skeletal muscles. The Journal of nutritional biochemistry, 18(1), 39-45.
Cheng, Y., Tian, D.-Y., & Wang, Y.-J. (2020). Peripheral clearance of brain-derived Aβ in Alzheimer's disease: pathophysiology and therapeutic perspectives. Translational neurodegeneration, 9, 1-11.
Davoodi, M., Moosavi, H., & Nikbakht, M. (2012). The effect of eight weeks selected aerobic exercise on liver parenchyma and liver enzymes (AST, ALT) of fat liver patients.
Delwing-de Lima, D., Ulbricht, A. S. S. F., Werlang-Coelho, C., Delwing-Dal Magro, D., Joaquim, V. H. A., Salamaia, E. M., . . . Desordi, L. (2018). Effects of two aerobic exercise training protocols on parameters of oxidative stress in the blood and liver of obese rats. The journal of physiological sciences, 68, 699-706.
Dinamarca, M.C., Arrázola, M., Toledo, E., Cerpa, W.F., Hancke, J., & Inestrosa, N.C. (2008). Release of acetylcholinesterase (AChE) from β-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. Chemico-biological interactions,175(1-3),142-149.
Ellinger, J. J., Lewis, I. A., & Markley, J. L. (2011). Role of aminotransferases in glutamate metabolism of human erythrocytes. Journal of biomolecular NMR, 49, 221-229.
Eze, E., Dawud, F., Zainab, A., Jimoh, A., Malgwi, I., & Isa, A. (2012). Preliminary studies of effects of vitamin C and zinc on some liver enzymes in alloxan-induced diabetic wistar rats. Asian J Med Sci, 4(1), 17-22.
Fernandes, M. S. d. S., Silva, L. d. L. d. S. e., Kubrusly, M. S., Lima, T. R. L. d. A., Muller, C. R., Américo, A. L. V., ... Lagranha, C. J. (2020). Aerobic exercise training exerts beneficial effects upon oxidative metabolism and non-enzymatic antioxidant defense in the liver of leptin deficiency mice. Frontiers in Endocrinology, 11, 588502.
Ferri, E., Rossi, P. D., Scichilone, M., Lucchi, T. A., & Arosio, B. (2022). Liver Enzymes in a Cohort of Community-Dwelling Older Persons: Focus on Sex Contribution. Nutrients, 14(23), 4973.
Giovanna, C., Cecchi, C., Pensalfini, A., Bonini, S. A., Ferrari-Toninelli, G., Liguri, G., ... Uberti, D. (2010). Generation of reactive oxygen species by beta amyloid fibrils and oligomers involves different intra/extracellular pathways. Amino acids, 38, 1101-1106.
GÖKBEL, H. (2006). Acute exercise induced oxidative stress and antioxidant changes. European Journal of General Medicine, 3(3), 126-131.
Gomez-Cabrera, M.-C., Domenech, E., & Viña, J. (2008). Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free radical biology and medicine, 44(2), 126-131.
Gouras, G. K., Olsson, T. T., & Hansson, O. (2015). β-Amyloid peptides and amyloid plaques in Alzheimer’s disease. Neurotherapeutics, 12, 3-11.
Jamali, J. S. K., N. (2018). The effect of vitamin C consumption on liver damage after methotrexate consumption in rats. Quarterly Journal of Medical Sciences, Islamic Azad University, Tehran Medical Branch, 28(1), 44-49.
Korivi, M., Hou, C.-W., Huang, C.-Y., Lee, S.-D., Hsu, M.-F., Yu, S.-H., ... Kuo, C.-H. (2012). Ginsenoside-Rg1 protects the liver against exhaustive exercise-induced oxidative stress in rats. Evidence-Based Complementary and Alternative Medicine, 2012.
Lange, K.W., Lange, K.M., Nakamura, Y., & Li, S. (2020). Do natural antioxidants play a role in Alzheimer’s disease? Journal of Food Bioactives, 11.
Lee, S.-P., Mar, G.-Y., & Ng, L.-T. (2009). Effects of tocotrienol-rich fraction on exercise endurance capacity and oxidative stress in forced swimming rats. European journal of applied physiology, 107, 587-595.
Lue, L.-F., Guerra, A., & Walker, D. G. (2017). Amyloid beta and tau as Alzheimer’s disease blood biomarkers: promise from new technologies. Neurology and therapy, 6, 25-36.
McGill, M. R. (2016). The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI journal, 15, 817.
Mehri, A. (2020). Effect of 8 weeks aerobic training and supplementation of resveratrol on oxidative marker MDA and Antioxidant SOD and GPX cardiomyocytes tissue in streptozotocin-diabetic rats.
Melo, C. S., Rocha-Vieira, E., Freitas, D. A., Soares, B. A., Rocha-Gomes, A., Riul, T. R., . . . Carvalho, L. E. D. (2019). A single session of high-intensity interval exercise increases antioxidants defenses in the hippocampus of Wistar rats. Physiology & behavior, 211, 112675.
Michalczyk, M., Kłapcińska, B., Sadowska-Krępa, E., Jagsz, S., Pilis, W., Szołtysek-Bołdys, I., . . . Kempa, K. (2008). Evaluation of the blood antioxidant capacity in two selected phases of the training cycle in professional soccer players. Journal of Human Kinetics, 19(2008), 93-108.
Monacelli, F., Acquarone, E., Giannotti, C., Borghi, R., & Nencioni, A. (2017). Vitamin C, aging and Alzheimer’s disease. Nutrients, 9(7), 670.
Moradi, A., & Moradi, F. (2019). The Effect of Eight Weeks of Sprint Interval Training on Levels of Lipocalin-2, Lipid Profile, Body Composition and Some Components of Physical Fitness of Young Female Volleyball Players: A Randomized Clinical Trial. Journal of Rafsanjan University of Medical Sciences, 18(8), 769-782.
Nasiri, E., Ansar, M., Gazor, R., & Rahmani, A. (2015). The effect of vitamin C on formaldehyde-induced liver injury in male rats. Journal of North Khorasan University of Medical Sciences, 6(4), 947-955.
Paknia, S., Sharif, M. A. S., & Heidarianpour, A. (2022) The Effect of Resistance Training Along with Hawthorn Supplementation on Some Indices of Oxidative Stress in Alzheimer's Male Rats.
Paolisso, G., Balbi, V., Volpe, C., Varricchio, G., Gambardella, A., Saccomanno, F., ... D'Onofrio, F. (1995). Metabolic benefits deriving from chronic vitamin C supplementation in aged non-insulin dependent diabetics. Journal of the American College of Nutrition, 14(4), 387-392.
Pillon Barcelos, R., Freire Royes, L. F., Gonzalez-Gallego, J., & Bresciani, G. (2017). Oxidative stress and inflammation: liver responses and adaptations to acute and regular exercise. Free radical research, 51(2), 222-236.
Rai, A. R., Madhyastha, S., Rao, G. M., Rai, R., & Sahu, S. S. (2013). A comparison of resveratrol and vitamin C therapy on expression of BDNF in stressed rat brain homogenate. IOSRJ Pharm, 3(10), 22-27.
Ramos, D., Martins, E.G., Viana-Gomes, D., Casimiro-Lopes, G., & Salerno, V.P. (2013). Biomarkers of oxidative stress and tissue damage released by muscle and liver after a single bout of swimming exercise. Applied Physiology, Nutrition, and Metabolism, 38(5), 507-511.
Ranjbar, K., Nazem, F., & Hashemi, S. (2016). Effect of Continuous Aerobic Training on Serum Levels of Liver Injury Indices in Rats with Myocardial Infarction.
Scheltens, P., Blennow, K., Breteler, M. M., De Strooper, B., Frisoni, G. B., Salloway, S., & Van der Flier, W. M. (2016). Alzheimer's disease. The Lancet, 388(10043), 505-517.
Selkoe, D. J., & Hardy, J. (2016). The amyloid hypothesis of Alzheimer's disease at 25 years. EMBO molecular medicine, 8(6), 595-608.
Shamsoddini, A., Sobhani, V., Chehreh, M. E. G., Alavian, S. M., & Zaree, A. (2015). Effect of aerobic and resistance exercise training on liver enzymes and hepatic fat in Iranian men with nonalcoholic fatty liver disease. Hepatitis monthly, 15(10).
Slattery, K., Bentley, D., & Coutts, A. J. (2015). The role of oxidative, inflammatory and neuroendocrinological systems during exercise stress in athletes: implications of antioxidant supplementation on physiological adaptation during intensified physical training. Sports Medicine, 45, 453-471.
Soltaniyan, M., Shariati, M., & Sharifi, E. (2016). Protective Effect of Vitamin C on Liver Tissue and Function in Female Newborns from the Mothers Treated with Lead Acetate.
Usefpor, M., Ghasemnian, A. A., & Rahmani, A. (2017). The Effect of a period of high intensive interval training on total antioxidant capacity and level of liver tissue malondialdehyde in male Wistar rats. Scientific Journal of Kurdistan University of Medical Sciences, 22(5), 103-110.
Vakili, J., Sasan, R. A., & Ordibazar, F. (2019). Effect of 8 weeks endurance training with Chlorella Vulgaris supplementation on liver enzymes levels in women with type 2 diabetes. Medical Journal of Tabriz University of Medical Sciences, 40(6), 88-97.
Verdile, G., Keane, K. N., Cruzat, V. F., Medic, S., Sabale, M., Rowles, J., ... Newsholme, P. (2015). Inflammation and oxidative stress: the molecular connectivity between insulin resistance, obesity, and Alzheimer’s disease. Mediators of inflammation, 2015.
Vesali Akbarpour, L., & Samavati Sharif, M. A. (2016). A Comparison of the Effect Two Methods of Endurance Swimming Training and Vitamin C Supplement on Liver Injury Biomarkers in Male Wistar Rats. Sport Physiology & Management Investigations, 8(3), 93-101.
Zolfeghar Didani, H., Kargarfard, M., & Azad Marjani, V. K. (2012). The Effects of Vitamin Supplementation on Oxidative Stress Indices after Anaerobic Activity in Water Polo Players. Journal of Isfahan Medical School, 30(199). | ||
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