پیوندهای مفید
اخبار و اعلانات
آمار
| تعداد نشریات | 41 |
| تعداد شماره‌ها | 1,129 |
| تعداد مقالات | 9,651 |
| تعداد مشاهده مقاله | 17,547,809 |
| تعداد دریافت فایل اصل مقاله | 12,253,441 |
اثر پیش تغذیه روغن دانه کتان (Linum usitatissimum) بر نفوذپذیری سدخونی- مغزی در مدل سکته مغزی موش صحرایی | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| مقاله 2، دوره 4، شماره 3، بهمن 1394، صفحه 13-20 اصل مقاله (396.03 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| نویسندگان | ||
| سید وحید حسینی1؛ مهدی رهنما*1؛ محمدرضا بیگدلی2 | ||
| 1دانشگاه آزاد اسلامی زنجان | ||
| 2دانشگاه شهید بهشتی تهران | ||
| چکیده | ||
| چکیده ادم ایسکمیک مغزی از مهمترین عوارض سکته مغزی میباشد. هدف از این مطالعه بررسی اثر پیش تغذیه روغن دانه کتان بر نفوذپذیری سد خونی مغزی در مدل سکته مغزی موش صحرایی میباشد. در این تحقیق تجربی حیوانات به طور تصادفی به 3 گروه آزمایشی، شم و کنترل تقسیم گردیدند که گروه آزمایشی خود شامل 3 گروه دریافتکننده روغن دانه کتان با دوزهای 25/0، 5/0 و 75/0 میلیلیتر بر کیلوگرم وزن بدن به مدت 30 روز بود. گروه کنترل آب مقطر دریافت میکردند، در حالی که برای گروه شم تیمار و القای ایسکمی صورت نمیگرفت. دو ساعت بعد از آخرین دوز خوراکی گروهها تحت جراحی مدل MCAO (انسداد شریان میانی مغز) به منظور القای ایسکمی و بررسی میزان نفوذپذیری سد خونی مغزی از طریق اندازهگیری میزان جذب نوری اوانس آبی (Evans Blue) قرار گرفتند. دادهها با استفاده از آزمون ANOVA تجزیه و تحلیل شدند. کاهش نفوذپذیری سد خونی مغزی در گروههای با دوز 5/0 و 75/0، در برابر گروه شاهد از لحاظ آماری معنیدار بود (05/0P | ||
| کلیدواژه‌ها | ||
| روغن دانه کتان؛ سد خونی- مغزی؛ سکته مغزی؛ موش صحرایی | ||
| عنوان مقاله [English] | ||
| The effect of pre-feeding flaxseed oil (Linum usitatissimum) on blood brain barrier permeability in rat stroke model | ||
| نویسندگان [English] | ||
| S. V. Hosseini1؛ M Rahnema1؛ MR Bigdeli2 | ||
| چکیده [English] | ||
| Abstract Ischemic Brain Edema is one of the most important complications of a stroke. This study aims to investigate the impact of pre-feeding of flax seed oil on blood-brain barrier in rat stroke model. In this experimental study animals were randomly divided into 3 groups of experiment, sham, and control. Each testing group itself was consisted of 3 subgroups receiving doses of Flaxseed oil with 0.25, 0.5 and 0.75 ml / kg of body weight for 30 days. The control group received distilled water, while therapy and ischemia induction were not done for sham group. In order to conduct ischemia induction and evaluating the permeability of the blood-brain barrier by measuring the optical density level of the Evans Blue MCAO (Middle Cerebral Artery Occlusion) model surgery was conducted on groups two hours after the last feeding dose. The data were analyzed via ANOVA test. The permeability decrease of the blood-brain barrier in groups with doses of 0.5 and 0.75 ml against the control group was statistically significant (P˂0/05). There were significant differences between the right and left hemispheres in control groups with dose of 0.25ml (P˂0/05).But the differences between the right and left hemispheres in therapy group with doses of 0.5 and 0.75 were insignificant. According to the findings of this study, pre-treatment with flax seed oil can reduce the permeability of the blood-brain barrier in a model of ischemia-reperfusion in rats. But still more works to extend these observations including the investigation of neurological deficits are needed to be done. | ||
| کلیدواژه‌ها [English] | ||
| Flax seed oil, blood-brain barrier, stroke, rats | ||
| مراجع | ||
|
Arvindkumar, E. G.; Suresh, S. J.; Subhash, L. B.; (2011). Renoprotective effect of linum usitatissimum seeds though haemodynamic changes and conservation of antioxidant enzymes in renal ischemia-reperfusion injury in rats. Arab J Urol; 9(3): 215-221.
Albishri, WM.; (2013). Favorable effect of flaxseed supplemented diet on liver and kidney function in hypertensive wistar rats. J Oleo Sci; 62(9): 709-715.
Anand, A. Z.; Mahabaleshwar, V. H.; Subhash, L. B.; (2013). protective role of concomitant administration of flax lignan concentrate and omega-3-fatty acid on myocardial damage in doxorubicin-induced cardiotoxicity. Food Science and Human Wellness; 2(1): 29-38.
Bigdeli, MR.; Hajizadeh, S.; Froozandeh, M.; Heidarianpour, A.; Rasoulian, B.; Asgari, AR.; Pourkhalili, K.; Khoshbaten, A.; (2008). Normobaric hyperoxia induces ischemic tolerance and upregulation of glutamate transporters in the rat brain and serum TNF-alpha level. Exp Neurol; 212 (2): 298-306.
Bhatia, AL.; Manda, K.; Patni, S.; Sharma, AL.; (2006). Prophylactic action of linseed (linum usitatissimum) oil against cyclophosphamide-induced oxidative stress in mouse brain. Journal of Medicinal Food; 9(2): 261-4.
Draganescu, D.; Ibanescu, C.; Tamba, B. I.; Andritoiu, C.V.; Dodi, G.; Popa, M.I.; (2015). Flaxseed lignan wound healing formulation: Characterization and in vivo therapeutic evaluation. International Journal of Biological Macromolecules; 72: 614-623.
Fishman, RA.; (1992). Cerebrospinal fluid in diseases of the nervous system. 2nded, W.B. Sunders Co. Philadelphia; 32: 103-155.
Hadjinikolaou, L.; Kotidis, K.; Galinanes, M.; (2004). Relationship between reduced elasticity of extracardiac vessels and left main stem coronary artery disease. European Heart Journal; 25(6): 508-513.
Jullie, K.M.; Jianmin, C.; Lilian, U.T.; (2010). Flaxseed oil_trastuzumab interaction in breast cancer. Food Chem Toxicol; 48(8-9): 2223-2226.
Johansson, BB.; (2011). Current trends in stroke rehabilitation. A review with focus on brain plasticity. Acta Neurol Scand; 123(3): 147-59.
Longa, EZ.; Weinstein, PR.; Carlson, S.; Cummins, R.; (1989). Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke; 20(1): 84-91.
Lundgren, J.; Zhang, H.; Agarh, CD.; Smith, ML.; Evans, PJ.; Halliwell, B.; Siesjo, BK.; (1991). Acidosis-induced ischemic brain damage: are free radicals involved? J Cereb Blood Flow Metab; 11(4): 587-596.
Marmarou, A.; (2004). The pathophysiology of brain edema and elevated intracranial pressure. Cleveland Clinic Journal of Medicine; 71(1): S6-S8.
Mani, UV.; Mani, I.; Biswas, M.; Kumar, SN.; (2011). An open-label study on the effect of flax seed powder (linum usitatissimum) supplementation in the management of diabetes mellitus. Journal of Dietary Supplements; 8(3): 257-65.
Mirmiran, P.; Esmailzadeh, A.; Azizi, F.; (2004). Detection of cardiovascular risk factors by anthropometric measures in tehranian adults: receiver operating characteristic (ROS) curve analysis. European Journal of Clinical Nutrition; 58(8): 1110-8.
Oomah, BD.; (2001). Flaxseed as functional source. Journal of the Science of Food and Agriculture; 81: 889-894.
Otranto, M.; Do Nascimento, AP.; Monto-Alto-Costa, A.; (2010). Effects of supplementation with different edible oils on cutaneous wound healing. Wound Rapair Regen; 18(6): 629-636.
Prasad, K.; (2009). Flaxseed and cardiovascular health. J Cardiovasc Pharmacol; 54(5): 369-377.
Pradillo JM, Hurtado O, Romera C, Moro MA, Leza JC, Davalos A, Castillo J, Lorenzo P, Lizasoain I. TNFR1 mediates increased neuronal membrane EAAT3 expression after in vivo cerebral ischemic preconditioning. Neuroscience 2006; 138(4): 1171-8.
Rosenberg, GA.; (1999). Ischemic brain edema. Prog Cardiovasc Dis; 42(3): 209-16.
Razi, SS.; Latif, MJ.; Li, X.; Afthinos, JN.; Ippagunta, N.; Schwartz, G.; Belsley, SJ.; Connery, CP.; Jour, G.; Christofidou-solomidou, M.; (2011). Dietary flaxseed protects against lung ischemia reperfusion injury via inhibition of apoptosis and inflammation in a murine model. Journal of Surgical Research; 171(1): 113-21.
Rabiei, Z.; Bigdeli, MR.; Rasoulian, B.; (2013). Neuroprotection of dietary virgin oil on brain lipidomics during stroke. Current Neurovascular Research; 10(3): 231-7.
Rami, A.; Bechmann, I.; Sthehle, JH.; (2008). Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog Neurobiol; 85(3): 273-296.
Selevani, A.; Sohrabji, F.; (2010). The neurotoxic effects of estrogen on ischemic stroke in older female rats is associated with age-dependent loss of insulin-like growth factor-1. The Journal of Neuroscience; 30(20): 6852-61.
Schuier, FJ.; Hossmann, KA.; (1980). Experimental brain infarcts in cats.II. ischemic brain edema. Stroke; 11(6): 593-601.
Rizwan, S.; Naqshbandi, A.; Farooqui, Z.; Khan, A.A.; Khan, F.; (2014). Protective effect of dietary flaxseed oil on arsenic-induced nephrotoxicity and oxidative damage in rat kidney. Food and Chemical Toxicology; 68: 99-107. | ||
|
آمار تعداد مشاهده مقاله: 2,151 تعداد دریافت فایل اصل مقاله: 1,051 |
||