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پیشرفتهای اخیر در سلول درمانی ضایعات نخاعی | ||
فصلنامه علمی زیست شناسی جانوری تجربی | ||
مقاله 5، دوره 5، شماره 2، آذر 1395، صفحه 35-51 اصل مقاله (573.6 K) | ||
نوع مقاله: مقاله پژوهشی | ||
نویسندگان | ||
شیوا نعمتی* 1؛ ابراهیم شهبازی2؛ مهدی حصارکی2؛ سحر کیانی3؛ رضا حاجی حسینی4 | ||
1دانشجوی دکتری بیوشیمی، دانشگاه پیام نور مرکز تهران و پژوهشگر پژوهشکده سلولهای بنیادی، پژوهشگاه رویان | ||
2دانشجوی دکتری زیستشناسی تکوینی، دانشگاه علم و فرهنگ و پژوهشگر پژوهشکده سلولهای بنیادی، پژوهشگاه رویان | ||
3استادیار، فیزیولوژی جانوری، عضو هیات علمی پژوهشکده سلولهای بنیادی، پژوهشگاه رویان | ||
4استاد، عضو هیات علمی، دانشگاه پیام نور مرکز تهران شرق | ||
چکیده | ||
ضایعه نخاعی شرایط تخریبیای است که هزینههای زیادی را بر بیمار و جامعه او تحمیل میکند و متأسفانه تاکنون هیچ درمان مؤثری برای بیماریهای سیستم عصبی و بالاخص ضایعات نخاعی ارائه نشده است. پیوند سلولهای بنیادی یک استراتژی امیدوارکننده است که البته هنوز در ابتدای راه بوده و آزمایشات و کارآزمائیهای بالینی بسیاری قبل از رسیدن آن به کلینیک باید به انجام و تایید مجامع پزشکی برسد. تحقیقات در زمینه بیولوژی سلولهای بنیادی و باز برنامه نویسی سلولها بهسرعت در حال پیشرفت بوده و امید دست یابی به درمان کلینیکی پیوند سلولی را در بین بیماران مبتلا به این ضایعه افزایش میدهد. در این مطالعه، اپیدمیولوژی ضایعه نخاعی، پاتوفیزیولوژی و آزمایشات و کارآزماییهای بالینی انجام شده را مورد بحث و بررسی قرار خواهیم داد. همچنین مطالعه معضلات موجود برای استفاده کلینیکی از استراتژی پیوند سلولی و پیشرفتهای اخیر در زمینه استفاده از سلولهای بنیادی جنینی انسانی برای پیوند به افراد مبتلا به ضایعه نخاعی از مباحث ارائه شده در مقاله حاضر میباشد. | ||
کلیدواژهها | ||
سلولهای بنیادی؛ ضایعه نخاعی؛ پیوند سلولی؛ کارآزمایی بالینی | ||
عنوان مقاله [English] | ||
Recent Advances in Cell therapy of spinal cord injury | ||
نویسندگان [English] | ||
Shiva Nemati1؛ Ebrahim Shahbazi2؛ Mehdi Hesaraki2؛ Sahar Kiani3؛ Reza Haji Hossein4 | ||
1Ph.D. Candidate in Biochemistry, Payame Noor University, Tehran Iran. And Researcher in Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran | ||
2Ph.D. candidate in Developmental Biology, Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran | ||
3Professor Asistant, Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. | ||
4Professor in Biochemistry, Payame Noor university, Tehran, Iran | ||
چکیده [English] | ||
Spinal cord injury (SCI) is a devastating condition producing great personal and societal costs and for which there is no effective treatment. Stem cell transplantation is a promising therapeutic strategy, though much preclinical and clinical research work remains. Here, we briefly describe SCI epidemiology, pathophysiology, and transplantation trial in human developments, including termination of the first human embryonic stem cell experimental and clinical stem cell strategies. Research in stem cell biology and cell reprogramming is rapidly advancing, with the hope of moving stem cell therapy closer to helping people with SCI. We examine issue important for clinical translation and provide a commentary on recent SCI. | ||
کلیدواژهها [English] | ||
stem cell, Spinal cord injury, Cell transplantation, Clinical translation | ||
مراجع | ||
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