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Indirect Determination of Anticancer Drug Capecitabine Using Hollow Fiber Supported Multiwalled Carbon Nanotube Coated on Polyurethane Foam | ||
Iranian Journal of Analytical Chemistry | ||
مقاله 2، دوره 5، شماره 2، آذر 2018، صفحه 9-16 اصل مقاله (1.01 M) | ||
نوع مقاله: Full research article | ||
نویسندگان | ||
Fatemeh Moeinpour؛ Zarrin Eshaghi* | ||
Department of Chemistry, Payame Noor University, 19395-4697 Tehran, Iran | ||
چکیده | ||
The aim of this work was indirect determination of anti-cancer drug capecitabine using complexation with platinum (IV) and determination by graphite furnace atomic absorption spectroscopy (GFAAS). For this aim at first, the complex of platinum with capecitabine was performed and the ratio of drug to metal was evalutsd with several ways. In the all of these methods, the ligand to metal ratio of the Potassium hexachloroplatinate (IV) and capecitabine complex was found to be 2:1. The extraction process was carried out by the hollow fiber supported functionalized multiwalled carbon nanotubes/ polyurethane foam (fMWCNT/PUF) foam as the solid adsorbent in the solid phase microextraction mode. The amount of desorbed platinum ion has been indirectly used to measure the drug concentrations. Parameters affecting the hollow fiber-solid phase microextraction (HF-SPME) such as pH of the donor phase, donor phase volume, the sorbent type and desorption solvent were optimized. Calibration graph was plotted and a curve with a linear response range of the 3.32 to 98.17 µg mL -1 and a detection limit 0.38 µg mL -1 was obtained. | ||
کلیدواژهها | ||
Capecitabine؛ SPE Method؛ Indirect Determination؛ Graphite Furnace Atomic Absorption Spectroscopy | ||
عنوان مقاله [English] | ||
ارزیابی غیر مستقیم داروی ضد سرطان کپسیتابین با استفاده از فیبر منخلخل حمایت شده با فوم پلی اورتان/ نانولوله های کربنی عاملدار | ||
نویسندگان [English] | ||
فاطمه معین پور؛ زرین اسحاقی | ||
بخش شیمی، دانشگاه پیام نور، صندوق پستی 3697-19395 ، تهران، ایران | ||
چکیده [English] | ||
هدف از این کار اندازهگیری غیر مستقیم داروی کپسیتابین به کمک تهیه کمپلکس آن با یون پلاتین (IV) و اندازهگیری آن با اسپکترومتری جذب اتمی با کوره گرافیتی است. به این منظور ابتدا کمپلکس کپسیتابین و یون پلاتینیوم تهیه شد و نسبت دارو به فلز با روشهای مختلف تعیین گردید. در همه روشها مشخص شد که نسبت لیگاند به فلز برای کپسیتابین و پتاسیم هگزاکلروپلاتینات(IV) 2:1 میباشد. فرآیند استخراج توسط فیبر متخلخل حمایتشده با فوم پلی اورتان/ نانولوله چند دیواره عاملدار به عنوان جاذب جامد با سبک میکرواستخراج فاز جامد انجام شد. مقدار یون پلاتینیوم واجذب شده بصورت غیر مستقیم برای اندازهگیری غلظت دارو مورد استفاده قرار گرفت. پارامترهای موثر بر روش میکرواستخراج فاز جامد فیبر متخلخل مانند pH فاز دهنده، حجم فاز دهنده، نوع جاذب و حلال واجذبی بهینه شدند. منحنی کالیبراسیون رسم شد و محدوده خطی 32/3 تا 17/98 میکروگرم بر میلیلیتر با حد تشخیص 38/0 میکروگرم بر میلیلیتر بدست آمد. در نهایت روش برای تشخیص و اندازهگیری داروی ضد سرطان کپسیتابین در نمونههای حقیقی به کار برده شد. | ||
کلیدواژهها [English] | ||
کپسیتابین, پتاسیم هگزاکلروپلاتینات (IV), اندازهگیری غیرمستقیم, اسپکترومتری جذب اتمی با کوره گرافیتی | ||
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