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Moeinpour, Fatemeh, Moodi, Danial, Sarabi-Omoori, Haleh, Eshaghi, Zarrin. (1400). Exploiting of Green Synthesized Doped Metal Oxide Nanosensor for Electrochemical Determination of Aspirin and Ibuprofen in Biological and Pharmaceutical Samples. فصلنامه علمی زیست فناوری گیاهان زراعی, 8(2), 69-79. doi: 10.30473/ijac.2022.62513.1215
Fatemeh Moeinpour; Danial Moodi; Haleh Sarabi-Omoori; Zarrin Eshaghi. "Exploiting of Green Synthesized Doped Metal Oxide Nanosensor for Electrochemical Determination of Aspirin and Ibuprofen in Biological and Pharmaceutical Samples". فصلنامه علمی زیست فناوری گیاهان زراعی, 8, 2, 1400, 69-79. doi: 10.30473/ijac.2022.62513.1215
Moeinpour, Fatemeh, Moodi, Danial, Sarabi-Omoori, Haleh, Eshaghi, Zarrin. (1400). 'Exploiting of Green Synthesized Doped Metal Oxide Nanosensor for Electrochemical Determination of Aspirin and Ibuprofen in Biological and Pharmaceutical Samples', فصلنامه علمی زیست فناوری گیاهان زراعی, 8(2), pp. 69-79. doi: 10.30473/ijac.2022.62513.1215
Moeinpour, Fatemeh, Moodi, Danial, Sarabi-Omoori, Haleh, Eshaghi, Zarrin. Exploiting of Green Synthesized Doped Metal Oxide Nanosensor for Electrochemical Determination of Aspirin and Ibuprofen in Biological and Pharmaceutical Samples. فصلنامه علمی زیست فناوری گیاهان زراعی, 1400; 8(2): 69-79. doi: 10.30473/ijac.2022.62513.1215

Exploiting of Green Synthesized Doped Metal Oxide Nanosensor for Electrochemical Determination of Aspirin and Ibuprofen in Biological and Pharmaceutical Samples

Iranian Journal of Analytical Chemistry
دوره 8، شماره 2 - شماره پیاپی 16، آذر 2021، صفحه 69-79    اصل مقاله (946.93 K)
نوع مقاله: Full research article
شناسه دیجیتال (DOI): 10.30473/ijac.2022.62513.1215
نویسندگان
Fatemeh Moeinpour1؛ Danial Moodi2؛ Haleh Sarabi-Omoori1؛ Zarrin Eshaghi* 1
1Department of Chemistry, Payame Noor University, P.O. Box 19395-4697, Tehran, IRAN
2Department of Animal Science Engineering, Faculty of Agriculture, Shahid Bahonar University of Kerman, Kerman, Iran
چکیده

The aim of the present study was to develop electrochemical sensors based on pencil graphite electrode modified with green-caped ZnO, CdO nano particles and potassium tetra chloroplatinate (II), for a simple and fast simultaneous microextraction and determination of Aspirin (ASA) and Ibuprofen (IBU). The nanoparticles were initially synthesized by the use of four vegetable extracts including garlic, onion, green onion and cabbage. The fabricated nanoparticles and platinum were then deposited on the surface of a pencil graphite electrode and was used as a working electrode in a three electrodes system. The Taguchi experimental design was employed for investigating the effects different parameters. For this purpose, a Taguchi L16 orthogonal array (OA) design was applied and the results were confirmed by the ANOVA test. The electrochemical behavior of ASA and IBU at the modified electrodes, were studied. The calibration curves were linear in the range of 5.17to 134.0 µg.mL-1 and 3.13 to 231.0 µg.mL-1 for ASA and IBU respectively. The limits of detection for ASA and IBU was calculated to be 0.50 and 0.42 µg.mL-1 respectively. The modified sensor showed good performance for simultaneous analysis of ASA and IBU in biological and pharmaceutical samples.
کلیدواژه‌ها
Green-Caped ZnO/ CdO Nano Particles؛ Voltammetry؛ Aspirin؛ Ibuprofen؛ Platinum
عنوان مقاله [English]
بهره برداری از یک نانوحسگر دوپه شده ی اکسید فلزی سنتز شده سبز برای تعیین الکتروشیمیایی آسپرین و ایبوپروفن در نمونه های بیولوژیکی و دارویی
نویسندگان [English]
فاطمه معین پور1؛ دانیال مودی2؛ هاله سرابی اموری1؛ زرین اسحاقی1
1گروه شیمی، دانشکده علوم، دانشگاه پیام نور، تهران، ایران
2گروه مهندسی علوم دامی، دانشکده کشاورزی، دانشگاه شهید باهنر کرمان
چکیده [English]
چکیده
هدف از مطالعه حاضر، توسعه حسگرهای الکتروشیمیایی مبتنی بر الکترود گرافیتی اصلاح شده با ذرات اکسید روی، نانو ذرات CdO و پتاسیم تترا کلروپلاتینات (II)، برای یک میکرواستخراج همزمان ساده و سریع و تعیین آسپرین و ایبوپروفن بود. این نانوذرات در ابتدا با استفاده از چهار عصاره گیاهی شامل سیر، پیاز، پیاز سبز و کلم سنتز شدند. سپس نانوذرات و پلاتین ساخته شده بر روی سطح یک الکترود گرافیتی مدادی رسوب کردند و به عنوان یک الکترود کار در یک سیستم سه الکترودی مورد استفاده قرار گرفتند. برای بررسی اثرات پارامترهای مختلف از طرح آزمایشی تاگوچی استفاده شد. برای این منظور از طرح آرایه متعامد تاگوچی L16 (OA) استفاده شد و نتایج با آزمون ANOVA تایید شد. رفتار الکتروشیمیایی آسپرین و ایبوپروفن در الکترودهای اصلاح شده مورد بررسی قرار گرفت. منحنی های کالیبراسیون به ترتیب برای آسپرین و ایبوپروفن در محدوده 5.17 تا 134.0 میکروگرم بر میلی لیتر و 3.13 تا 231.0 میکروگرم بر میلی لیتر در لیتر خطی بودند. حدود تشخیص برای آسپرین و ایبوپروفن به ترتیب 0.50 و 0.42 میکروگرم بر میلی لیتر در لیتر محاسبه شد. حسگر اصلاح شده عملکرد خوبی برای آنالیز همزمان آسپرین و ایبوپروفن در نمونه های بیولوژیکی و دارویی نشان داد.
کلیدواژه‌ها [English]
نانوذرات ZnO/CdO با کلاه سبز, ولتامتری, آسپرین, ایبوپروفن, یون پلاتین
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