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Saberi, Ali. (1395). A facile and efficient synthesis of Baclofen. فصلنامه علمی زیست فناوری گیاهان زراعی, 4(Issue 2, pp. 133-235, Serial No. 11), 142-145.
Ali Saberi. "A facile and efficient synthesis of Baclofen". فصلنامه علمی زیست فناوری گیاهان زراعی, 4, Issue 2, pp. 133-235, Serial No. 11, 1395, 142-145.
Saberi, Ali. (1395). 'A facile and efficient synthesis of Baclofen', فصلنامه علمی زیست فناوری گیاهان زراعی, 4(Issue 2, pp. 133-235, Serial No. 11), pp. 142-145.
Saberi, Ali. A facile and efficient synthesis of Baclofen. فصلنامه علمی زیست فناوری گیاهان زراعی, 1395; 4(Issue 2, pp. 133-235, Serial No. 11): 142-145.

A facile and efficient synthesis of Baclofen

Iranian chemical communication
مقاله 2، دوره 4، Issue 2, pp. 133-235, Serial No. 11، تیر 2016، صفحه 142-145    اصل مقاله (83.77 K)
نوع مقاله: Original Research Article
نویسنده
Ali Saberi
Department of Chemistry, Payame Noor University, PO BOX 19395-4697 Tehran, Iran.
چکیده
γ-Aminobutiric acid (GABA), the major inhibitory neurotransmitter in the central nervous system is activated by the antispastic and muscle relaxant agent, Baclofen, which is a lipophilic derivative of GABA. Because of its biological and pharmacological importance, there are several reports in the literature about the synthesis of baclofen since 1962. In this study baclofen was easily synthesized by Claisen condensation of ethyl acetoacetate and p-chlorobenzaldehyde, formation of cyclic imide from β(p-chlorophenyl) glutaric acid and further Hoffmann rearrangement of β(p-chlorophenyl) glutarimid. Reagents used were inexpensive and commercially available. The overall yield of the reported strategy was 50% which is a good yield compare with other previous reports.
کلیدواژه‌ها
Baclofen؛ Synthesis؛ GABA receptor؛ γ-aminobutiric acid
مراجع
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