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Microwave-assisted synthesis of 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin and zinc derivative and study of their bacterial photoinactivation | ||
Iranian chemical communication | ||
مقاله 6، دوره 4، Issue 2, pp. 133-235, Serial No. 11، تیر 2016، صفحه 175-185 اصل مقاله (209.86 K) | ||
نوع مقاله: Original Research Article | ||
نویسندگان | ||
Rahmatollah Rahimi* 1؛ Fatemeh Fayyaz1؛ Mehdi Rassa2؛ Mahboubeh Rabbani3 | ||
1Bioinorganic Chemistry Laboratory, Department of Chemistry, Iran University of Science and Technology | ||
2Department of Biology, Faculty of Science, University of Guilan, Rasht, Iran | ||
3Department of Chemistry, Iran University of Science and Technology, | ||
چکیده | ||
In this study, 5,10,15,20-tetrakis(4-nitrophenyl)porphyrin (TNPP) and its zinc porphyrin complex (ZnTNPP) were synthesized in situ using the microwave method and identified by UV-Vis, FT-IR and 1H NMR. The photostability and photodynamic antimicrobial activity (PACT) of these compounds were investigated on Pseudomonas aeruginosa and Bacillus subtilis under visible light irradiation. MIC, MBC and inhibition zones produced by these compounds were determined and the number of bacteria counted. The results indicated that both compounds have significant stability when illuminated for various illumination periods in nutrient broth media. Both compounds exhibited more effective activity against P. aeruginosa than B. subtilis in nutrient agar. | ||
کلیدواژهها | ||
Antimicrobial activity؛ Bacillus subtilis؛ photoinactivation؛ pseudomonas aeruginosa؛ TNPP | ||
مراجع | ||
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