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Isoquinoline promoted Synthesis of alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives | ||
| Iranian chemical communication | ||
| مقاله 41، دوره 5، Issue 1, pp. 1-120, Serial No. 14، فروردین 2017، صفحه 52-57 اصل مقاله (113.64 K) | ||
| نوع مقاله: Original Research Article | ||
| نویسندگان | ||
| Rahimeh Hajinasiri* 1؛ Sanaz Baravardeh2؛ Sobhan Rezayati3 | ||
| 1Department of Chemistry, Islamic Azad University, Qaemshahr Branch, P.O. Box 163, Qaemshahr, Iran | ||
| 2Department of Chemistry, Qaemshahr Branch, Islamic Azad University, P.O. Box 163, Qaemshahr, Iran | ||
| 3Department of Chemistry, Payame Noor University, PO BOX 19395-4697, Tehran, Iran | ||
| چکیده | ||
| Derivatives of thiazolidinone ring systems are known to act as anti-HIV infections , analgesic, anti-bacterial, anti-convulsant, anti parasitic, potential anti-inflammatory and herbicidal agents. Due biological activities of thiazolidinones ring, several methods for their synthesis have been illustrated in literature. Imidazolidine-2-thiones were synthesized by the oxidative cyclization of 1-benzoyl-3-aryl-thioureas with bromine and enolizable carbonyl compounds in the presence of excess triethylamine . A suitable method for the synthesis of fused thiazoles were described from the reaction of aroylphenyl thioureas with π-acceptor quinones. An efficient and one-pot method for the synthesis alkyl 2-(1-alkyl-5-oxo-3-phenyl-2-thioxotetrahydro-4H-imidazol-4-yliden) acetate derivatives via simple reaction between isoquinoline, dialkyl acetylenedicarboxylate and benzyl phenylthiourea under solvent-free conditions without using any additional catalyst, is described. The mild reaction conditions and good yields and exhibit the synthetic advantage of this method. Also this method is environmentally friendly. | ||
| کلیدواژهها | ||
| Isoquinoline؛ solvent-free؛ benzyl phenylthiourea؛ imidazole؛ green chemistry | ||
| مراجع | ||
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