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Green and efficient synthesis of functionalized 3-amino-2-oxofuranes using trityl chloride | ||
| Iranian chemical communication | ||
| مقاله 8، دوره 5، Issue 4, pp. 364-493, Serial No. 17، دی 2017، صفحه 436-441 اصل مقاله (614.61 K) | ||
| نوع مقاله: Original Research Article | ||
| نویسندگان | ||
| Seyed Sajad Sajadikhah* 1؛ Mahboubeh Zarei2 | ||
| 1Department of Chemistry, Payame Noor University, Iran | ||
| 2Department of Chemistry, Payame Noor University (PNU), Iran | ||
| چکیده | ||
| Extremely facile and efficient procedure has been developed for the synthesis of alkyl 2,5-dihydro-2-oxo-5-aryl-3-(arylamino) furan-4-carboxylate in the presence of trityl chloride (TrCl) as an organic catalyst in ethanol at ambient temperature. One-pot three-component reaction of aromatic amines, dimethyl and/or diethyl acetylenedicarboxylates and aryl aldehydes offorded the corossponding 3-amino-2-oxofurane derivatives in good to high yields. The presented method offers several advantages such as green and mild conditions, simplicity of operation, non-toxicity of the catalyst and high atom economy. Moreover, the products were obtained through simple filtering and no need to column chromatography, which reduces the waste as well as environmental pollutions. | ||
| کلیدواژه‌ها | ||
| Heterocycle؛ 3-amino-2-oxofurane؛ trityl chloride؛ dialkyl acetylenedicarboxylate | ||
| مراجع | ||
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