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Nano Al2O3/KF using for synthesis of some Hantzsch type-products | |
Iranian chemical communication | |
مقاله 5، دوره 6، Issue 3, pp. 218-324, Serial No. 20، مهر 2018، صفحه 266-270 اصل مقاله (585.19 K) | |
نوع مقاله: Original Research Article | |
نویسندگان | |
Asadollah Farhadi* 1؛ Milad Ramyar2؛ Mohammad Ali Takassi2 | |
1Petroleum university of technology of ahwaz | |
2Petroleum University of Technology, Faculty of Science, Ahwaz, Iran, 61981-44471 | |
چکیده | |
A protocol for the synthesis of 1,4-dihydropyridines (Hantzsch type-products) was developed by means of a three-component condensation of an aldehyde, a β-dicarbonyl compound, ammonium acetate and nano Al2O3/KF as catalyst. This reaction was carried out under different conditions including i) solvent-free ii) and reflux in different solvents. In all conditions, the desired products were obtained in high yields after relatively short reaction times. Nevertheless, the reactions proceed faster and in higher yields when they were carried out in ethanol. Compared to the classical Hantzsch reaction conditions and previously reported protocols, this protocol has the advantages of consistently excellent yields and short reaction times. After the reaction, the catalyst could be recovered easily. | |
کلیدواژهها | |
Hantzsch type-products؛ 1؛ 4-dihydropyridines؛ Nano Al2O3/KF؛ ethanol؛ different solvents | |
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