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Synthesis, characterization and polymerization of a novel acrylate monomer containing both 4H-pyran-4-one and 1,2,3-triazole moiety and evaluation of their antibacterial activity | ||
Iranian chemical communication | ||
مقاله 6، دوره 6، Issue 3, pp. 218-324, Serial No. 20، مهر 2018، صفحه 271-279 اصل مقاله (811.92 K) | ||
نوع مقاله: Original Research Article | ||
نویسندگان | ||
Mahnaz Saraei* 1؛ Gholamreza Zarrini2؛ Parisa Rajabpour1 | ||
1Department of Chemistry, Payame Noor University, PO BOX 19395-3697 Tehran, Iran | ||
2Department of Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz-Iran | ||
چکیده | ||
A novel acrylate monomer containing 4H-pyran-4-one and 1,2,3-triazole ring, {1-[4-(4-oxo-6-phenyl-4H-pyran-2-yl)benzyl]-1,2,3-triazol-4-yl}methyl acrylate was synthesized by the reaction of 2-{4-[(4-(hydroxymethyl)-1,2,3-triazol-1-yl)methyl]phenyl}-6-phenyl-4H-pyran-4-one with acryloyl chloride in the presence of triethylamine. The structure of the acrylate monomer was established on the basis of FT-IR, 1H NMR, 13C NMR, MS and elemental analysis. This monomer was polymerized using 2,2´-azobisisobutyronitrile (AIBN) as the initiator in N,N-dimethylformamide solution. Thermal stability of the polymer was investigated by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The synthesized compounds were evaluated for their antibacterial activity against Gram-positive and Gram-negative bacteria using the disk diffusion method. The results of antibacterial assay indicated that these compounds exhibited moderate bactericidal activity. | ||
کلیدواژهها | ||
4H-Pyran-4-one؛ triazole؛ acrylate monomer؛ antibacterial activity؛ free radical polymerization؛ thermal properties | ||
مراجع | ||
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