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Nabati, Mehdi, Mahkam, Mehrdad. (1393). One-pot and one-step novel N-methylation of 2,6-diaminopyridine. فصلنامه علمی زیست فناوری گیاهان زراعی, 2(Issue 3, pp. 162-231, Serial No. 4), 162-167.
Mehdi Nabati; Mehrdad Mahkam. "One-pot and one-step novel N-methylation of 2,6-diaminopyridine". فصلنامه علمی زیست فناوری گیاهان زراعی, 2, Issue 3, pp. 162-231, Serial No. 4, 1393, 162-167.
Nabati, Mehdi, Mahkam, Mehrdad. (1393). 'One-pot and one-step novel N-methylation of 2,6-diaminopyridine', فصلنامه علمی زیست فناوری گیاهان زراعی, 2(Issue 3, pp. 162-231, Serial No. 4), pp. 162-167.
Nabati, Mehdi, Mahkam, Mehrdad. One-pot and one-step novel N-methylation of 2,6-diaminopyridine. فصلنامه علمی زیست فناوری گیاهان زراعی, 1393; 2(Issue 3, pp. 162-231, Serial No. 4): 162-167.

One-pot and one-step novel N-methylation of 2,6-diaminopyridine

Iranian chemical communication
مقاله 1، دوره 2، Issue 3, pp. 162-231, Serial No. 4، مهر 2014، صفحه 162-167    اصل مقاله (128.36 K)
نوع مقاله: Original Research Article
نویسندگان
Mehdi Nabati* ؛ Mehrdad Mahkam
Chemistry Department, Faculty of Science, Azarbaijan Shahid Madani University, Tabriz, Iran
چکیده
2,6-diaminopyridine is extensively used as a pharmaceutical intermediate and a hair dye coupler as oxidation formulations. It is soluble in protic solvents. Primary and secondary amines are N-methylated by various methods such as direct alkylation of amines with Hofmann mechanism, but in many of these methods due to overalkylations, we earn a mixture of amino products. Consequently, they aren't selective in secondary amines preparation. Also, the selective synthesis of secondary amines is a problematic field in organic chemistry. 2,6-diaminopyridine can be selective N-methylated from reaction of this compound with sodium azide and orthoformic ester in low time with good yields.
کلیدواژه‌ها
2,6-diaminopyridine؛ N-methylation؛ selectivity؛ one-pot reaction
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