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بررسی اثر هرنیارین بر رفتارهای اضطرابی و افسردگی متعاقب هیپوپرفیوژن-ایسکمی مزمن مغز در موشهای صحرایی نر | ||
فصلنامه علمی زیست شناسی جانوری تجربی | ||
دوره 9، شماره 3 - شماره پیاپی 35، بهمن 1399، صفحه 93-103 اصل مقاله (754.16 K) | ||
نوع مقاله: مقاله پژوهشی | ||
شناسه دیجیتال (DOI): 10.30473/eab.2020.48847.1740 | ||
نویسندگان | ||
زهرا نظری پرچستانی1؛ مریم رفیعی راد* 2 | ||
1استادیار، گروه زیستشناسی، دانشگاه آزاد اسلامی، واحد ایذه، ایذه، ایران | ||
2کارشناس، گروه زیستشناسی، دانشگاه آزاد اسلامی، واحد ایذه، ایذه، ایران | ||
چکیده | ||
ایسکمی در مغز موش موجب آسیبهای نورونی شدید و بهدنبال آن موجب اختلالات اضطرابی و افسردگی میگردد. هرنیارین ترکیبی فنلی دارد و آنتیاکسیدان قوی است. لذا هدف از این مطالعه بررسی اثر هرنیارین بر اضطراب و افسردگی در مدل ایسکمی در موشهای نر است. در این مطالعه تجربی، 50 سر موش صحرایی نر نژاد ویستار (250-200گرم) به پنج گروه شامل گروه کنترل، شاهد،ایسکمی و گروههای ایسکمی دریافتکننده 14روز، دوزهای 150 و 300 میلیگرم بر کیلو گرم هرنیارین به روش گاواژ تقسیم شدند. برای ایجاد ایسکمی شریانهای کاروتید عمومی دو طرفه جدا شده، از دو قسمت مسدود و از بخش میانی قطع شدند. ارزیابی اضطراب در طی تست جعبه باز انجام گرفت. همچنین برای سنجش افسردگی زمان بیحرکتی در شنای اجباری اندازهگیری شد. در موشهای ایسکمی افزایش معنیدار اضطراب و افزایش مدت زمان حرکتی در تست جعبه باز و شنای اجباری مشاهده گردید (001/0P<). در تجویز دوزهای 150 و300 میلیگرم بر کیلوگرم هرنیارین افزایش تعداد بالابردن دستها (001/0P<) و نیز کاهش معنیدار تعداد دفع در هر دوز مشاهده گردید (001/0P<) و مصرف دوز mg/kg150 و 300 هرنیارین در موشهای ایسکمی در تعداد عبور از مربعات در جعبه باز افزایش معنیدار را نشان داد (001/0P<). هرنیارین دارای اثرات ضد اضطرابی و ضد افسردگی در مدل تجربی ایسکمی میباشد. | ||
کلیدواژهها | ||
ایسکمی؛ اضطراب؛ افسردگی؛ موش صحرایی؛ هرنیارین | ||
عنوان مقاله [English] | ||
The effect of herniarin on anxiety behaviors and depression following chronic cerebral ischemia hypoperfusion in male rats | ||
نویسندگان [English] | ||
Zahra Nazari Parchestani1؛ Maryam Rafieirad2 | ||
1Assistant Professor, Department of Biology, , Izeh Branch, Islamic Azad University, Izeh, Iran | ||
2M.A., Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran | ||
چکیده [English] | ||
Ischemia in rat brain causes severe neuronal damage and consequently anxiety and depression disorders. The herniarin has a phenolic compound and is a powerful antioxidant. The aim of this study was to investigate the effect of herniarin on anxiety and depression in ischemia model in male rats. In this experimental study, 50 male Wistar rats(200-250g) were divided into 5 groups: control group, sham and ischemic group and ischemic groups receiving doses of 150 and 300 mg/kg herniarin by gavage method. To induce ischemia, bilateral carotid arteries were separated, blocked in two, and cut off in the middle section. Anxiety assessment was performed during the open-box test. Immobility time in forced swimming was also measured to measure depression. In the ischemic rats a significantly increased anxiety and an increase of mobility duration in both open box and forced swimming tests were observed (P<0.001). When the doses of 150-300 mg/kg herniarin was prescribed the times of elevation of hands was increased (P<0.001) and a significantly reduction of excretion times in each dose was observed (P<0.001) and consumption of herniarin doses 150-300 mg/kg was significantly increased in the ischemicrats when they passed several times through squares in the open box (P<0.001). herniarin has the effect of both anti-anxiety and- depression in the experimental model. | ||
کلیدواژهها [English] | ||
Anxiety, depression, herniarin, ischemia, rat | ||
مراجع | ||
Abbasi Maleki, S.; Bekhradi, R.; Asgharpanah, J.; Abbasi Maleki, F.; and Maleki Ahanghari, N. (2013). Antidepressant-like effect of aqueous and hydroalcoholic extracts of Lavandula angustifolia Mill in forced swim test and tail suspension test in male mice. Arak Med. Univ. J; 16: 65-75.
Amsterdam, JD.; Li, Y.; Soeller, I.; Rockwell, K.; Mao, JJ.; Shults, J. (2009). randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy forgeneralized anxiety disorder. J Clin Psychopharmacol; 29(4): 378-82.
Amsterdam, JD.; Li, Y.; Soeller, I.; Rockwell, K.; Mao, JJ.; Shults, J. (2009). A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol; 29(4): 378-82.
Amsterdam, JD.; Shults, J.; Soeller, I.; Mao, JJ.; Rockwell, K.; Newberg, AB. (2012). Chamomile (Matricaria recutita) may provide antidepressant activity in anxious, depressed humans: an exploratory study. Altern Ther Health Med;18(5):44-9.
Avallone, R.; Zanoli, P.; Puia, G.; Kleinschnitz, M.; Schreier, P.; Baraldi, M. (2000). Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol; 59(11): 1387-94.
Aydin, T.; Serkan Ero, H.; Cakir, A.; Yildirim, S.; Selim, Y.; Halici, M. (2017). Effects of herniarin on sepsis induced rats’ liver. J Pharma Care Health Sys; 4: 4 (Suppl)
Basile, DP.; Yoder, MC. (2014). Renal endothelial dysfunction in acute kidney ischemia reperfusion injury. Cardiovasc Haematol Disord-Drug Targets; 14: 3e14.
Bouayed, J.; Bohn, T. (2010). Exogenous antioxidants-double-edged swords in cellular redox state: Health beneficial effects at physiologic doses versus deleterious effects at high doses. Oxid Med Cell Longev; 3(4): 228-37.
Bouayed, J.; Rammal, H.; Soulimani, R. (2009). Oxidative stress and anxiety: relationship and cellular pathways. Oxid Med Cell Longev; 2(2): 63-7.
Eidipour, E.; Rafieirad, M.; Alami Rostami, Sh.; And Zangenenezhad, Z. (2018). Anti-depressive effects of hydroalcoholic extract of Chevilan (Ferulago angulate Boiss.) in adult male wistar rat model of ischemia/ hypoperfusion. Nova Biologica Rep; 137-143.
Hovatta, I.; Tennant, RS.; Helton, R. (2005). Glyoxalase 1 and glutathione reductase 1 regulate anxiety in mice. Nature; 438(7068): 662-6.
Ivanovska, N.; Phlipov, S.(2018). Apoptosis induction by auraptene, umbelliprenin and herniarin in MCF-7 cells. Int J Ethnopharmacol; 64(2): 161-66.
Komeili, G.; Fanaei, H.; Sarani, V.; (2016). Effects of Aqueous Matricaria Recutita extract on anxiety-like behavior in rat’s model kindled by Pentylenetetrazole. J Birjand Univ Med Sci; 23 (1) :21-28.
Lucassen, PJ.; Pruessner, J.; Sousa, N.; Almeida, OF.; Van Dam, AM.; Rajkowska, G.; Swaab, DF.; Czéh, B. (2014). Neuropathology of stress. Acta Neuropathol;127(1):109-35.
Mahmoudzadeh, L.; Najafi, H.; Changizi-Ashtiyani, S.; Mohamadi yarijani, Z. (2017). Antiinflammatory and protective effects of Saffron extract in ischemia-reperfusion induced acute kidney injury. Nephrology (Carlton); 22: 748e754.
Malan, L.; Hamer, M.; von Keanel, R. (2016). Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study. Nitric Oxide-Biol. Chem. 55-56, 10-17.
Mathew, SJ.; Price, RB.; Charney, DS. (2008). Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Am J Med Genet; 148 C(2): 89-98.
Mohammadzadeh, M.; Sharifzadeh, S.; Ilkhanipoor, M.; Nejati, V.; Heidari, R. (2018). Eff-ect of Aqueous Extract of Cinnamon on Anxiety-Like Behavior in Streptozotocin-Induced Diabetic Male Rats. Armaghane Danesh; 23(1): 57-68.
Molnar, M.; Mendesevic, N.; Subaric, D.; Banjari, I.; Jokic, S. (2017). Comparison of various techniques for the extraction of umbelliferone and herniarin in Matricaria chamomilla processing fractions. Chemistry Central Journal; 11(1): 78.
Paladini, AC.; Marder, M.; Viola, H.; Wolfman, C.; Wasowski, C.; Medina, JH. (1999). Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds. J Pharm Pharmacol; 51(5): 519-26.
Patil, P.A. (2013). Comprehensive review on synthesis and designing aspects of coumarin derivatives as monoamine oxidase inhibitors for depression and Alzheimer's disease. Bioorganic & Medicinal Chemistry. January; 21: 2434-2450.
Petrulova-Poracka, V.; Repcak, M.; Vilkova, M.; Imrich, J. (2013). Coumarins of Matricaria chamomilla L.: aglycones and glycosides. Food Chem; 141: 54-59.
Rabiei, Z.; Rafieian-Kopaei, M.; Mokhtari, S.; Shahrani, M. (2014). Effect of dietary ethanolic extract of Lavandula officinalis on serum lipids profile in rats. IJPR; 13(4): 1295-301.
Rafieirad, M.; Eydipour, Z.; Alami Rostami, S. (2018). Effects of Antidepressants Hydro-alcoholic extract of Chevilan (Ferulago angulate) in model of ischemia/ hypoperfusion in adult male rats. nbr; 5 (2): 137-143.
Rafieirad, M.; Eydipour, Z.; Alami Rostami, S. (2018). Effects of Antidepressants Hydro-alcoholic extract of Chevilan (Ferulago angulate) in model of ischemia/ hypoperfusion in adult male rats. nbr; 5 (2): 137-143.
Rafieirad, M.; Zangeneh Nezhad, Z. E. A. (2014). Neuroprotective Effects of Oral Ellagic Acid on Locomotor Activity and Anxiety-Induced by Ischemia/ Hypoperfusion in Rat. Advances in Environmental Biology;8(1):83-8.
Redaelli, C.; Formentini, L.; Santaniello, E. (1981). HPLC determination of coumarins in Matricaria chamomilla. Planta Med; 43: 412-413.
Rezaei, A.; Jafari, B.; Jalilzadeh, M.H. (2010). Study of sedative, preanaesthetic and anxiolytic effect of herbal extract of Lavandula Stoechas in comparison with diazepam. U Tabriz J; 3: 899-905.
Roomiani, L.; Soltani, M.; Akhondzadeh Basti, A.; Mahmoodi, A.; TaheriMirghaed, A.; Yadollahi, F. (2018). Evaluation of the chemical composition and in vitro antimicrobial activity of Rosmarinus officinalis, Zataria multiflora, Anethum graveolens and Eucalyptus globulus against Streptococcus iniae the cause of zoonotic disease in farmed fish. IJFS;12(3): 702-16.
Ross, SM. (2013). Generalized anxiety disorder (GAD): efficacy of standardized Matricaria recutita (German chamomile) extract in the treatment of generalized anxiety disorder. Holist Nurs Pract; 27(6): 366-8.
Salim, S.; Sarraj, N.; Taneja, M.; Saha, K.; Tejada-Simon, MV.; Chugh, G. (2010). Moderate treadmill exercise prevents oxidative stress-induced anxiety-like behavior in rats. Behav Brain Res; 208(2): 545-52.
Sarris, J.; Panossian, A.; Schweitzer, I.; Stough, C.; Scholey, A. (2011). Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol; 21(12): 841-60.
Simard, S.; Coppola, G.; Rudyk, C.A. (2018). Profiling changes in cortical astroglial cells following chronic stress. Neuropsycho pharmacology; 43 (9): 1961-1971.
Yamada, K.; Miura, T.; Mimaki, Y.; Sashida, Y. (1996). Effects of inhalation of chamomile oil vapour on plasma ACTH level in ovariectomized-rat under restriction stress. Biol Pharm Bull; 19(9): 1244-6. | ||
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