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Determining the Amount of Metronidazole Drug in Blood and Urine Samples With the help of PbS Sensor functionalized With Gelatin as a Fluorescence- Enhanced Probe. | ||
| Iranian Journal of Analytical Chemistry | ||
| مقاله 6، دوره 7، شماره 2 - شماره پیاپی 14، آذر 2020، صفحه 47-56 اصل مقاله (1.04 M) | ||
| نوع مقاله: Full research article | ||
| شناسه دیجیتال (DOI): 10.30473/ijac.2021.56671.1175 | ||
| نویسندگان | ||
| Shirin Bouroumand؛ Farzane Marahel* ؛ Fereydoon Khazali | ||
| Department of Chemistry, Omidiyeh Branch, Islamic Azad University, Omidiyeh, Iran | ||
| چکیده | ||
| Fluorescent chemical sensors to detect drugs, by increasing fluorescence emission and absorption or by shutting down, because they are non-destructive, the ability to show decomposed concentrations, fast response, high accuracy have been considered and used. In this research, a chemical sensor was synthesized PbS functionalized with gelatin quantum dots for (MNZ) drug. The calibration curve was linear in the range of (0.1 to 10.0 µg L−1). The standard deviation of (3.5%), and detection limit of the method (2.2 µg L−1 in time 50 sec, 285 nm) were obtained for sensor level response PbS Quantum Dot–Gelatin Nano composites sensor with (95%) confidence evaluated. The observed outcomes confirmed the suitability recovery and a very low detection limit for measuring the (MNZ) drug. The method fluorometric introduced to measure (MNZ) drug in real samples such as urine and blood was used and can be used for hospital samples. The chemical PbS Quantum Dot–Gelatin Nano composites sensor made it possible as an excellent sensor with good reproducibility. | ||
| کلیدواژهها | ||
| Metronidazole Drug؛ Fluorescence؛ Sensor؛ PbS with Gelatin Synthesis؛ Quantum Dots | ||
| عنوان مقاله [English] | ||
| تعیین مقدار داروی مترونیدازول در نمونه های خون و ادرار با کمک حسگرنانو ذرات نقاط کوانتومی سولفید سرب پوشش داده شده با ژلاتین به عنوان یک پروب افزایش یافته با فلوئوسانس عامل دار شده | ||
| نویسندگان [English] | ||
| شیرین برومند؛ فرزانه مراحل؛ فریدون خضعلی | ||
| گروه شیمی، دانشگاه آزاد اسلامی، واحد امیدیه، امیدیه، ایران | ||
| چکیده [English] | ||
| حسگرهای شیمیایی فلوئورسانس کننده برای شناسایی داروها، از طریق افزایش نشر فلوئورسانس و جذب و یا از طریق عمل خاموش کردن، به دلیل غیر مخرب بودن آن ها، توانایی نشان دادن غلظت های مورد تجزیه، پاسخ سریع، دقت و صحت بالا بسیار مورد توجه و استفاده قرار گرفته اند. در این تحقیق، حسگر شیمیایی با روشی آسان و کم هزینه از نانو ذرات کوانتومی سولفید سرب با پوششی از ژلاتین در حضور گلوتارالدئید برای تعیین میزان داروی مترونیدازول سنتز گردید. منحنی کالیبراسیون در محدوده (0.1 تا 10.0 میکروگرم در لیتر) خطی بود. انحراف استاندارد روش(3.5٪) و حد تشخیص روش (2.2 میکروگرم در لیتر، در مدت زمان 50 ثانیه، در طول موج 285 نانومتر) برای داروی مترونیدازول محاسبه گردید. و ارزیابی زمان پاسخ دهی دارو در طول موج 285 نانو متر در حضور حسگر شیمیایی نانوذرات سولفید سرب پوشش داده شده با ژلاتین در مدت زمان 50 ثانیه با در صد اطمینان 95درصد حاصل گردید. نتایج مشاهده شده بهبود مناسب بودن و حد تشخیص بسیار کم برای اندازه گیری دارو (MNZ) را تأیید کرد. از روش فلوئورسنجی برای اندازه گیری دارو (MNZ) در نمونه های حقیقی مانند ادرار و خون استفاده شد و می تواند برای دیگر نمونه داروها و همچنین نمونه های بیمارستانی مورد استفاده قرار گیرد. حسگر شیمیایی نانو ذرات کوانتومی سولفید سرب با پوششی از ژلاتین این امکان را به عنوان یک سنسور عالی با قابلیت تکرارپذیری خوب فراهم کرده است. | ||
| کلیدواژهها [English] | ||
| داروی مترونیدازول, فلوئورسانس, حسگر سنتزی سولفید سرب با پوشش ژلاتین, اتصالات کوانتومی عرضی | ||
| مراجع | ||
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