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Anion-Doped Overoxidized Polypyrrole/Multiwalled Carbon Nanotubes Modified Glassy Carbon Electrode as a New Electrochemical Sensing Platform For Buprenorphine Opioid Drug | ||
| Iranian Journal of Analytical Chemistry | ||
| دوره 8، شماره 1 - شماره پیاپی 15، خرداد 2021، صفحه 56-64 اصل مقاله (827.16 K) | ||
| نوع مقاله: Full research article | ||
| شناسه دیجیتال (DOI): 10.30473/ijac.2021.59410.1194 | ||
| نویسندگان | ||
| Abdolhamid Hatefi-Mehrjerdi* 1؛ ُُSoghra Rafiei Boldaji1؛ Mohammad Reza Yaftian2؛ Hassan Shayani-Jam2 | ||
| 1Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-4697, Tehran, Iran | ||
| 2Department of Chemistry, Faculty of Science, University of Zanjan, P.O. Box 45371-38791, Zanjan, Iran | ||
| چکیده | ||
| A novel Buprenorphine (BPR) sensor is fabricated based on nanocomposite film of benzene-1,3-disulfonate anion doped overoxidized polypyrrole/multiwalled carbon modified glassy carbon electrode. The carbon nanotubes were drop-casted on bare electrode, and then thin layer of benzene-1,3-disulfonate-doped overoxidized polypyrrole formed electrochemically on it. Effect of experimental conditions involving supporting electrolyte pH, carbon nanotubes suspension drop size, and the number of potential cycles in overoxidized polymerization were optimized by monitoring the voltammetry responses of the modified electrode. Then the optimized modified electrode was used for electrochemical sensing of BPR by differential pulse voltammetry, which exhibited a linear growth with high sensitivity in anodic peak currents at the BPR concentration range of 0.06-40 µM, and a detection limit of 28 nM. Finally, the determination of BPR in urine real samples was performed by the new sensor and satisfactory results obtained. | ||
| کلیدواژه‌ها | ||
| Buprenorphine؛ Multiwalled Carbon Nanotubes؛ Overoxidized Polypyrrole؛ Nanocomposite؛ Electrochemical Sensor؛ Differential Pulse Voltammetry | ||
| عنوان مقاله [English] | ||
| الکترود کربن شیشه ای اصلاح شده با پلی پیرول اوراکسیدایز آنیون داپ شده برروی نانولوله های کربن چنددیواره به عنوان پلتفرم حسگر جدید الکتروشیمیایی داروی مخدر بوپرنورفین | ||
| نویسندگان [English] | ||
| عبدالحمید هاتفی مهرجردی1؛ صغری رفیعی بلداجی1؛ محمد رضا یافتیان2؛ حسن شایانی جم2 | ||
| 11. گروه ﺷﻴﻤﻲ، داﻧﺸﮕﺎه ﭘﻴﺎم ﻧﻮر، ﺻﻨﺪوق پستی 3697-19395، ﺗﻬﺮان، اﻳﺮان | ||
| 22. گروه شیمی، دانشگاه زنجان، صندوق پستی 38791-45371، زنجان، ایران | ||
| چکیده [English] | ||
| یک حسگر جدید بوپرنورفین (BPR) بر اساس الکترود کربن شیشه ای اصلاح شده با با پلی پیرول اوراکسیدایز داپ شده با آنیون بنزن-1و3-دی سولفونات برروی نانولوله های کربن چنددیواره ساخته شده است. نانولوله های کربنی بر روی یک الکترود برهنه تخلیه و خشک شدند و سپس یک لایه نازک از پلی پیرول اوراکسیدایز داپ شده با بنزن-1و3-دی سولفونات به صورت الکتروشیمیایی روی آن تشکیل شد. اثر شرایط آزمایش شامل pH الکترولیت حامل، اندازه قطره سوسپانسیون نانولوله های کربنی و تعداد چرخه های پتانسیل در پلیمریزاسیون اضافه اکسید شده با نظارت بر پاسخ های ولتامتری الکترود اصلاح شده، بهینه سازی شد. سپس از الکترود اصلاح شده بهینه سازی شده برای اندازه گیری الکتروشیمیایی BPR توسط ولتامتری پالس دیفرانسیل استفاده شد که یک رشد خطی با حساسیت بالا در جریان های پیک آندی در محدوده غلظت 40-0.06 میکرومولار از BPR و حد تشخیص 28 نانومولار نشان داد. سرانجام ، اندازه گیری BPR در نمونه های واقعی ادرار توسط حسگر جدید انجام شد و نتایج رضایت بخشی به دست آمد. | ||
| کلیدواژه‌ها [English] | ||
| بوپرنورفین, نانولوله های کربن چنددیواره؛ پلی پیرول اوراکسیدایز؛ نانوکامپوزیت؛ حسگر الکتروشیمیایی؛ ولتامتری پالس تفاضلی | ||
| مراجع | ||
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