Simple spectrophotometric methods for quantification of modafinil using 1,2-naphthoquinone-4-sulphonate and 2,4-dinitrophenol as analytical reagents

Seshamamba, Burla Sunitha; Satyanarayana, Peruri Veera; Sekharan, Chandra

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	Simple spectrophotometric methods for quantification of modafinil using 1,2-naphthoquinone-4-sulphonate and 2,4-dinitrophenol as analytical reagents
Iranian chemical communication
مقاله 3، دوره 2، Issue 4, pp. 236-325, Serial No. 5، دی 2014، صفحه 255-268 اصل مقاله (367.14 K)
نوع مقاله: Original Research Article
نویسندگان
Burla Sunitha Seshamamba¹؛ Peruri Veera Satyanarayana²؛ Chandra Sekharan^* ³
¹Department of Biotechnology, Jagarlamudi Kuppuswamy Choudary College, Guntur, Andhra Pradesh-522006, India.
²Department of Biochemistry, Acharya Nagarjuna University, Guntur, Andhra Pradesh-522510, India.
³Department of Food Chemistry and Nutrition, College of Food Science and Technology, Bapatla, Andhra Pradesh-522101, India.
چکیده
Two simple visible spectrophotometric methods are developed and validated for the quantification of modafinil using 1,2-naphthoquinone-4-sulphonic acid (NQS method) and 2,4-dinitrophenol (DNP method) as analytical reagents. The NQS method involves the reaction of modafinil with 1,2-naphthoquinone-4-sulphonate in alkaline medium at room conditions to form a yellow colored product exhibiting maximum absorption at 430 nm. DNP method is based on the proton transfer from 2,4-dinitrophenol to modafinil at room conditions and then we have the formation of yellow colored ion-pair complex exhibiting maximum absorption at 475 nm. Different variables affecting the reaction were studied and optimized. Under the optimized experimental conditions, Beer's law is obeyed in the concentration ranges of 10-100 and 8-60 μg/mL with the detection of limit values of 0.486 and 0.258 μg/mL for NQS method and DNP method, respectively The molar absorptivity and Sandell's sensitivity for both of the methods are reported. The methods were validated in terms of accuracy, precision and robustness. The results were satisfactory. The proposed methods were effectively applied to the analysis of the modafinil in their tablet formulations. The recoveries were 99.92% and 99.96% with RSD and 0.863% and 0.722% for NQS and DNS methods, respectively. The assay was not interfered by common excipients.
کلیدواژه‌ها
Narcoleptic drug؛ naphthoquinone-4-sulphonic acid؛ dinitrophenol؛ Spectrophotometry؛ Analysis

مراجع
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آمار

Simple spectrophotometric methods for quantification of modafinil using 1,2-naphthoquinone-4-sulphonate and 2,4-dinitrophenol as analytical reagents

[1] P. Gerrard, R. Malcolm, Neuropsychiatr. Dis. Treat., 2007, 3, 349–364.

[5] J.L. Donovan, R.J. Malcolm, J.S. Markowitz, C.L. DeVane, Therap. Drug Monitor., 2003, 25, 197-202.

[13] V. Venkatesh, N. Vijaya Lakshmi, P. Venkata Suresh, P. Mohana rao, K. Siva, G. Dhana Raju, N. Rama Rao, J. Pharma. Res., 2011, 4, 509-512.

[14] C. Narasimha, B. Raju, G.D. Rao, K. Swetha, Int. Cur. Pharm. J., 2012, 1, 77-80.

[15] K. Swetha, S. Mohideen, T. Satyanarayana, C.H. Narasimha, P.S. Kumar, M. Shyamala, Int. J. Res. Pharm. Biomed. Sci., 2011, 2, 1837-1840.

[16] R. Nageswara Rao, D.D. Shinde, M.V.N. Kumar Talluri, Talanta, 2007, 73, 407–414.

[17] A.A. Khan, S.K. Panda, S.S. Kumar, D.A. Kumar, Int. J. Bio. Pharm. Res., 2011, 2, 39-44.

[18] V. Chaudhary, M. Ubale, Int. J. Pharm. Chem. Sci., 2013, 2, 207-213.

[19] G.P. Pandya, H.S. Joshi, IOSR J. Pharma. Bio. Sci., 2013, 5, 22-28.

[21] A.A. Elbashir, A.H.E. Elwagee, J. Asso. Arab Universities Basic Appl. Sci., 2012, 11, 32–36.

[22] Q.M. Li, Z.J. Yang, Spectrochim. Acta. A Mol. Biomol. Spectrosc., 2007, 66, 656-661.

[23] Q. Li, J. Li, Z. Yang, Anal. Chim. Acta., 2007, 583, 147-152.

[24] S.A. Abdulrahman, K. Basavaiah, Int. J. Anal. Chem., 2011, 2011, 619310.

[25] M.A. Omar, D.M. Nagy, M.A. Hammad, A.A. Aly, J. Appl. Pharma. Sci., 2013, 3, 151-161.

[26] Y. Li, Z. Yansheng, X. Chunsheng, W. Wenlong, J. Chinese Pharma. Sci., 2001, 10, 196-199.

[27] H.A. Benesi, J. Hidelbrand, J. Am. Chem. Soc., 1949, 71, 2703-2707.

[28] A.N. Martin, J. Swarbrick, A. Cammarata, Physical Pharmacy; 3rd ed., Lee& Febiger, Philadelphia: PA, 1969, pp. 344.

[29] Validation of Analytical Procedures; Methodology, International Conference on Harmonization (ICH): Text and Methodology Q2 (R 1): Complementary Guideline on Methodology dated 06 November 1996: incorporated in November 2005, London.