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مقایسه بیان ژن گیرنده های دوپامینرژیک به عنوان نشانگر مولکولی در بیماران افسرده عمده و افراد سالم | ||
| عصب روان شناسی | ||
| دوره 7، شماره 25، مرداد 1400، صفحه 43-58 اصل مقاله (481.29 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/clpsy.2020.55775.1572 | ||
| نویسندگان | ||
| ویدا آقازاده1؛ عباس ابوالقاسمی* 2؛ محمد ضعیفی زاده3؛ علی رضایی شریف4 | ||
| 1کارشناسی ارشد روانشناسی بالینی، دانشگاه علوم پزشکی اردبیل، اردبیل، ایران. | ||
| 2دانشیار، گروه روانشاسی، دانشکده علوم انسانی، دانشگاه گیلان، گیلان، ایران. | ||
| 3استادیار، گروه ژنتیک، دانشکده پزشکی، دانشگاه آزاد اسلامی اردبیل، اردبیل، ایران. | ||
| 4دانشیار گروه مشاوره دانشگاه محقق اردبیلی، دانشکده علوم‌تربیتی و روانشناسی، اردبیل، ایران. | ||
| چکیده | ||
| مقدمه: این مطالعه با‌هدف مقایسه بیان ژن گیرنده‌های دوپامینرژیک DRD3 و DRD4 دربیماران مبتلا به افسردگی اساسی و افراد سالم انجام شد. روش: این پژوهش از نوع علی – مقایسه‌ای است. جامع آماری شامل کلیه بیماران افسرده مراجعه کننده در سال 1398 به کلینیک‌های روانپزشکی بود. از این جامعه 62 نفر از بیماران افسرده اساسی (28 مرد و 34 زن) به روش نمونه‌گیری در دسترس و 60 نفر فرد سالم (30 مرد و 30 زن) به‌عنوان گروه مقایسه انتخاب شدند. پس از اخذ رضایت از افراد و برای اندازه گیری بیان نسبی ژن‌های DRD3 و DRD4 از روش‌های Real-Time RT-PCR و SYBER Green استفاده شد. یافته‌ها: ژن DRD3 در بیماران افسرده نسبت به افراد سالم بیان نسبی کمتری داشت (P<0.001)، اما در بیان ژن DRD4 در بین دو گروه اختلاف معنی‌داری مشاهده نگردید (P>0.05). نتیجه گیری: یافته‌ها حاکی از آن است که گیرنده DRD3 مارکر مهمی در افسردگی است که می توان از آن برای تایید تشخیص و درمان مناسب (MDD) استفاده کرد. | ||
| کلیدواژه‌ها | ||
| اختلال افسردگی عمده؛ بیان ژن؛ گیرنده DRD3؛ گیرنده DRD4 | ||
| عنوان مقاله [English] | ||
| Dopaminergic Receptors Gene Expression a Molecular Marker for Major Depression and Healthy Individuals | ||
| نویسندگان [English] | ||
| vida aghazadeh1؛ Abbas Abolghasemi2؛ Mohammad Zaefizadeh3؛ Ali Rezaei sharif4 | ||
| 1M.A of Clinical psychologist , Ardabil University of Medical Sciences, Ardabil ,Iran. | ||
| 2Associate Professor, Department of Psychology, Faculty of Humanities, University of Guilan, Guilan, Iran. | ||
| 3Assistant Professor, Department of Genetics, School of Medicine, Islamic Azad University of Ardabil, Ardabil, Iran | ||
| 4Associate Professor, Department of Counseling, Mohaghegh Ardabili University, Faculty of Educational Sciences and Psychology, Ardabil, Iran. | ||
| چکیده [English] | ||
| Introduction: Major depression is the most common psychiatric disorder and in the world has the greatest impact of all biomedical diseases on disability. The purpose of the present study is comparing the expression of dopaminergic DRD3 and DRD4 receptors in patients with major depression and healthy Individuals. Methods: The population of this study was, all depressed patients admitted to the clinical psychologists. The method is causal-comparative study. The research sample includes of 62 depressed patients (28 male and 34 female), with the random sampling of depressed patients referred to the clinics, to be selected, and 60 healthy individuals(30 male and 30 female) as comparison group. After the informed consent.Evaluate the relative expression of gene DRD3 and DRD4, using measured by quantitative Real-Time RT-PCR and SYBER Green used. Research data was analyzed using the T-Test, SPSS and Excel software. Results: Results showed that DRD3 gene in patients compared to healthy subjects had greater relative expression(p value<0.001),but the D4 gene expression in the two groups showed no significant difference (p >0.05).The finding suggest that DRD3 gene seem to be important variables in depression, but DRD4genedoes not play a role in depression. Conclusions: The finding suggest that he DRD3 receptor gene seem to be an important variable in depression, which showed decreased expression of receptor DRD3,under the influence of this disease, which we can be used as a marker for to screen major depression disorder (MDD) correctly. | ||
| کلیدواژه‌ها [English] | ||
| MDD, gene expression, DRD3, DRD4 receptors | ||
| مراجع | ||
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