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اثر چهار هفته تمرین تناوبی شدید همراه با مکمل‌دهی تریپتوفان بر شاخصهای آسیب قلبی در موش‌های صحرایی سالمند مبتلا به دیابت | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| دوره 11، شماره 2 - شماره پیاپی 42، آذر 1401، صفحه 77-89 اصل مقاله (544.44 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2023.64932.1883 | ||
| نویسندگان | ||
| منصور فرج الهی مقدم1؛ ام البنین قاسمیان* 2 | ||
| 1گروه دامپزشکی، واحد شوشتر، دانشگاه آزاد اسلامی، شوشتر، ایران | ||
| 2گروه دامپزشکی، واحد بهبهان، دانشگاه آزاد اسلامی، بهبهان، ایران | ||
| چکیده | ||
| دیابت میلتوس یکی از بزرگ‌ترین مشکلات سلامت جهانی است که احتمال بروز آن با افزایش سن بیش‌تر میشود. سالانه، تعداد زیادی از سالمندان به‌دلیل بیماریهای قلبی عروقی ناشی از ارتباط سالمندی و اختلالات متابولیکی جان خود را از دست می‌دهند. هدف از پژوهش حاضر بررسی اثر چهار هفته تمرین تناوبی شدید همراه با مکمل تریپتوفان بر شاخصهای آسیب قلبی شامل لاکتات دهیدروژناز (LDH)، CK-MB، آسپارتات‌ترانس‌آمیناز (AST) در موش‌های صحرایی سالمند مبتلا به دیابت بود. در این مطالعه تجربی تعداد 40 سر موش صحرایی سالمند مبتلا به دیابت به‌طور تصادفی به چهار گروه ده نفره کنترل، شم، تمرین تناوبی با شدت بالا (HIIT) و HIIT به‌علاوه مصرف پودر تریپتوفان تقسیم شدند. مصرف مکمل تریپتوفان با دوز 50 میلی‌گرم بر کیلوگرم صورت گرفت. در نهایت، سطح LDH، AST و کراتین کیناز (CK-MB) بین گروه‌ها مقایسه شد. یافتهها حاکی از ان بود که مقادیر LDH، CK-MB و AST در گروه کنترل دیابتی به‌طور معنی‌داری بالاتر از گروه کنترل سالم بود (05/0=P). مقادیر LDH در گروه HIIT+ تریپتوفان به‌طور معنی‌داری کم‌تر از گروه کنترل دیابتی بود (03/0=P) و مقادیر AST در گروههای تریپتوفان (001/0=P)، HIIT (001/0=P) و HIIT+ تریپتوفان (001/0=P) به‌طور معنی‌داری کم‌تر از گروه کنترل دیابتی بود. به‌نظر می‌رسد شاخصهای نشانگر بیماری قلبی با تمرینات ورزشی و مصرف تریپتوفان بهبود مییابد. با این‌حال، در ارتباط با شدت و نوع تمرین و هم‌چنین دوز مصرفی تریپتوفان مطالعات بیش‌تری موردنیاز است. | ||
| کلیدواژه‌ها | ||
| تمرین تناوبی؛ تریپتوفان؛ شاخصهای آسیب قلبی؛ موش صحرایی | ||
| عنوان مقاله [English] | ||
| Effect of Four Weeks of Intense Interval Training Along with Tryptophan Supplementation Consumption on Cardiac Damage Index in Diabetic Elderly Rats | ||
| نویسندگان [English] | ||
| Mansour Farajollahi Moghadam1؛ Omolbanin Ghasemian2 | ||
| 1Department of Veterinary, Shoushtar Branch, Islamic Azad University, Shoushtar, Iran | ||
| 2Department of Veterinary, Behbahan Branch, Islamic Azad University, Behbahan, Iran | ||
| چکیده [English] | ||
| Diabetes mellitus is one of the most serious global health problems, and its occurrence increases with age. Considering the relationship between aging and metabolic disorders, it seems that each year a large number of elderly people die due to cardiovascular diseases caused by these factors. The present study aimed to investigate the effect of four weeks of intense interval training along with the consumption of tryptophan supplementation on cardiac damage index in elderly diabetic rats. In this experimental study, 40 diabetic elderly rats were randomly divided into four groups, each group having 10 rats. These were control, sham, high-intensity interval training (HIIT), and HIIT+tryptophan supplementation (at a dose of 50 mg/kg) groups. The levels of lactate dehydrogenase (LDH), aspartate transaminase (AST), and creatine kinase-MB (CK-MB) was measured in each group. The results showed that the levels of LDH, AST, and CK-MB in the diabetic control group were significantly higher compared to the healthy control group (P= 0.05). Moreover, the LDH level in the HIIT + tryptophan group was significantly lower than that in the diabetic control group (P= 0.03). AST levels in the tryptophan, HIIT (P=0.001), and HIIT+tryptophan groups (P=0.001) were significantly lower compared to the diabetic control group (P= 0.001). Based on the obtained results, the indicators of heart disease improved with exercise and consumption of tryptophan. However, further studies are recommended to investigate the effects of intensity and type of training as well as the dosage of tryptophan in this regard. | ||
| کلیدواژه‌ها [English] | ||
| Heart Damage index, Interval Training Rats, Tryptophan | ||
| مراجع | ||
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