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A new facile route to synthesize thieno[3,2-e][1,2,4]triazolo[4,3-c]pyrimidine derivatives | ||
| Iranian chemical communication | ||
| مقاله 6، دوره 3، Issue 2, pp. 72-147, Serial No. 7، تیر 2015، صفحه 114-120 اصل مقاله (674.69 K) | ||
| نوع مقاله: Original Research Article | ||
| نویسندگان | ||
| Mehdi Soleimany* 1؛ Jalil Lari2؛ Hooshang Vahedi2؛ Morteza Imanpour2 | ||
| 1Payame Noor University (PNU) | ||
| 2Payame Noor University of Mashhad | ||
| چکیده | ||
| A new facile route for synthesis of 3- (aryl) -8, 9- di (alkyl) thieno [3,2-e] [1,2,4] triazolo pyrimidines derivative from the same starting material, 2- amino - 4,5 -di (alkyl) thiophene-3- carboxamide, has been developed through heterocyclization of the corresponding arylidene-hydrazino -5,6 -di (alkyl) thieno [2,3-d] pyrimidine under refluxing condition with acetic anhydride followed by air oxidation. The products were obtained in high yield with an easy work-up in simple reaction along with the purification of products by non-chromatographic method. This general synthetic procedure can be extended to the preparation of a wide variety of isomeric triazoles using 2-amino thiophene-3-carboxamide bifunctional derivatives. | ||
| کلیدواژهها | ||
| Thieno[3؛ 2-e][1؛ 2؛ 4]triazolo[4؛ 3-c]pyrimidines heterocyclization acetic anhydride air oxidation | ||
| مراجع | ||
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