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اثر درمانی ترکیب عصاره هیدروالکلی گل سیر و سولفات روی بر مقدار هماتوکریت در موش صحرایی نر دیابتیشده با استرپتوزوتوسین | ||
| فصلنامه علمی زیست شناسی جانوری تجربی | ||
| مقاله 4، دوره 7، شماره 4 - شماره پیاپی 28، اردیبهشت 1398، صفحه 39-46 اصل مقاله (197.97 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.30473/eab.2019.5689 | ||
| نویسندگان | ||
| نامدار یوسف وند* 1؛ وحید حسنوند2 | ||
| 1استادیار فیزیولوژی، گروه زیستشناسی، دانشکده علوم، دانشگاه رازی، کرمانشاه، ایران | ||
| 2کارشناس ارشد زیستشناسی- فیزیولوژی جانوری، دانشگاه رازی، کرمانشاه، ایران | ||
| چکیده | ||
| چکیده تأثیر مثبت سیر بر دیابت و کاهش عوارض آن شناخته شده است. عنصر روی نیز تأثیرات درمانی سودمندی درحیوانات دیابتی و انسان دارد. هدف از این مطالعه بررسی اثر درمانی ترکیب عصاره گل سیر و سولفات روی بر مقدار هماتوکریت در دیابت القاشده با استرپتوزوتوسین (STZ) در موشهای صحرایی نر بود. تعداد 21 سر موش صحرایی نر بالغ نژاد ویستار به 3 گروه تقسیم شدند (7n=). گروه شاهد (شم)، که درطول 45 روز از آب و غذای معمولی استفاده کردند و در آغاز دوره به آنها نرمال سالین تزریق شد، کنترل مثبت (دیابتیشده بهوسیله STZ با دوز mg/kg40 در شروع دوره) و گروه درمانی عصاره گل سیر+ سولفات روی، این گروه بلافاصله بعد از اینکه STZ دریافت کردند و از دیابتی شدن آنها اطمینان حاصل شد تحت درمان با عصاره گل سیر با غلظت mg/Lit 360 و سولفات روی با غلظت mg/Lit 36 در آب آشامیدنی تا پایان دوره (45) قرارگرفتند. هماتوکریت خون با استفاده از دستگاه Diatron مدل ABACUS-c (ساخت اتریش) بهصورت خودکار اندازه گیری شد. هماتوکریت در گروه تحت تیمار که عصاره هیدروالکلی گل سیر و سولفات روی را بهصورت ترکیب دریافت کرده بودند نسبت به کنترل افزایش معناداری را نشان داد (001/0>p). نتایج بهدستآمده بیانگر آن است که ترکیب عصاره گل سیر و سولفات روی در آب آشامیدنی باعث افزایش میزان هماتوکریت در موش صحرایی با دیابت القایی میگردد. | ||
| کلیدواژهها | ||
| واژههای کلیدی: سولفات روی؛ گل سیر؛ موش دیابتیشده؛ هماتوکریت | ||
| عنوان مقاله [English] | ||
| Therapeutic effect of garlic flower extract and zinc sulphate combined on hematocrit in streptozotocin-induced diabetic rats | ||
| نویسندگان [English] | ||
| Namdar Yousofvand1؛ Vahid Hasanvand2 | ||
| 1Assistant Professor, Department of Biology, Faculty of Science, Razi University, Kermanshah, Iran | ||
| 2M.Sc. of Biology Animal Physiology, Razi University, Kermanshah, Iran | ||
| چکیده [English] | ||
| Abstract The positive effects of garlic on diabetes and its complications are known. Zinc also has beneficial therapeutic effects on diabetes in diabetic animals and humans. The aim of this study was to evaluate the therapeutic effect of combination of garlic flower extract and zinc sulfate on hematocrit in streptozotocin (STZ)-induced diabetic rats. Twenty-one adult male Wistar rats were divided into 3 groups (n=7). Which include: Sham group that received usual water and food for 45 days and were injected normal saline on first day of beginning of this time period Positive control group (diabetic) which they received usual food and water during 45 days and they were injected streptozotocin (STZ) at a dose 40mg/kg (intraperitoneal injection) on first day of beginning of this time period. The treated group with garlic flower extract + zinc sulfate, immediately after receiving STZ and ensuring of their diabetes they were treated with garlic extract of 360 mg/Lit and zinc sulfate at a concentration of 36 mg/Lit in drinking water during 45-day period. The hematocrits were measured automatically, using Diatron device, model ABACUS-c (Austria). Hematocrit in the treated group, which received the hydroalcoholic extract of garlic flower and zinc sulfate in combination, showed a significant increase compared to control (p | ||
| کلیدواژهها [English] | ||
| Keywords: Diabetic rats, Garlic flowers, Hematocrit, Zinc sulphate | ||
| مراجع | ||
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